Predictive value of STMN1 gene promoter polymorphism (-2166T>C) in patients with advanced NSCLC treated with the combination of platinum compounds and vinorelbine.

Author: CiesielkaMarzanna, HomaIwona, KoziołPiotr, KrawczykPaweł, Małecka-MassalskaTeresa, MilanowskiJanusz, MlakRadosław, PowrózekTomasz, PrendeckaMonika

Paper Details 
Original Abstract of the Article :
The combination of platinum compounds and vinorelbine is often used as a first-line treatment in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), without activating EGFR mutations and ALK rearrangement. Unfortunately, less than half of the patients benefit from chemot...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540763/

データ提供:米国国立医学図書館(NLM)

Predicting Chemotherapy Response in Lung Cancer: Insights from STMN1 Gene

Non-small cell lung cancer (NSCLC) is a challenging disease, and personalized medicine is crucial for optimizing treatment strategies. This research focuses on a specific gene, STMN1, and investigates its potential to predict the effectiveness of platinum-based chemotherapy in NSCLC patients. The study examines the relationship between a specific genetic variant in the STMN1 gene and the response to chemotherapy.

Decoding the STMN1 Gene: A Potential Key to Personalized Lung Cancer Treatment

The study reveals that a specific polymorphism in the STMN1 gene promoter (STMN1 -2166T>C) may predict the effectiveness of chemotherapy in NSCLC patients. This finding suggests that analyzing this gene variant could help clinicians personalize treatment plans, potentially leading to better treatment outcomes and reducing the side effects of chemotherapy. It's like having a compass that guides us to the most effective treatment path for each patient, taking into account their individual genetic landscape.

Towards Tailored Treatment: Understanding STMN1 for Lung Cancer Patients

The study's findings highlight the importance of considering genetic factors when designing chemotherapy regimens. By analyzing the STMN1 gene, clinicians can potentially identify patients who are more likely to benefit from platinum-based chemotherapy, allowing for more personalized and effective treatment plans.

Dr.Camel's Conclusion

This research emphasizes the importance of personalized medicine in lung cancer treatment. Imagine the STMN1 gene as a hidden oasis in the vast desert of NSCLC. By analyzing this gene, we can decipher its secrets and identify the right treatment strategy for each patient, potentially improving their chances of survival. This study serves as a reminder that understanding individual genetic profiles is crucial in the fight against cancer.

Date :
  1. Date Completed 2015-12-17
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

26220844

DOI: Digital Object Identifier

PMC4540763

Related Literature

SNS
PICO Info
in preparation
Languages

English

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