In Vivo Effects of Preservative-free and Preserved Prostaglandin Analogs: Mouse Ocular Surface Study.

Author: JungJae-Chang, KimEun Joo, KimJee Hyun, KimYeoun-Hee, KimYong Il, LeeKyoo Won, LeeSe-Hyung, ParkYoung Jeung

Paper Details 
Original Abstract of the Article :
Chronic use of topical hypotensive agents induces several side effects caused by preservatives. The purpose of this study was to evaluate the effects of prostaglandin analogs with varying concentrations of benzalkonium chloride (BAC), preservative-free (PF), and alternative preservatives on mouse co...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520871/

データ提供:米国国立医学図書館(NLM)

Prostaglandin Analogs: Navigating the Desert of Ocular Surface Effects

The world of ocular surface health, like a vast and delicate desert ecosystem, requires careful consideration of the potential effects of medications. This study, like a meticulous desert botanist examining the impact of different substances on the ecosystem, investigates the effects of prostaglandin analogs, a common class of eye medications, on the mouse corneal tissue. The researchers explore the impact of varying concentrations of preservatives, including benzalkonium chloride (BAC), on corneal health, seeking to identify potential risks and minimize adverse effects.

Navigating the Impact of Preservatives

This study provides valuable insights into the potential impact of preservatives on corneal health. The researchers found that prostaglandin analogs with varying concentrations of benzalkonium chloride (BAC) can have significant effects on mouse corneal tissue. This discovery, like the discovery of a hidden desert spring with a potential for both benefit and risk, underscores the importance of considering the potential impact of preservatives in ophthalmic medications.

Protecting the Ocular Surface: A Delicate Balance

This study, like a delicate dance through the desert dunes, highlights the importance of balancing therapeutic benefits with the potential risks associated with preservatives in ophthalmic medications. The researchers' findings emphasize the need for continued research and development of alternative preservatives that can minimize adverse effects on the ocular surface. By navigating this complex landscape, we can work towards preserving the health and integrity of this essential part of the human body.

Dr.Camel's Conclusion

This study, like a reminder to tread carefully in the desert, underscores the importance of considering the impact of preservatives on ocular surface health. The research findings emphasize the need for a balanced approach, ensuring that the benefits of ophthalmic medications outweigh the potential risks associated with preservatives.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

26240512

DOI: Digital Object Identifier

PMC4520871

Related Literature

SNS
PICO Info
in preparation
Languages

English

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