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Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome.

Author: BayramNeriman, MolBen Willem J, NahuisMarleen, Van der VeenFulco, WeissNienke S, van WelyMadelon

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

There was no evidence of a difference in live birth and ovarian hyperstimulation syndrome rates between urinary-derived gonadotropins and recombinant FSH or HMG/HP-HMG in women with polycystic ovary syndrome (PCOS) and clomiphene citrate resistance or failure.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Ovulation induction with follicle stimulating hormone (FSH) is the second-line treatment in women with polycystic ovary syndrome (PCOS) who do not ovulate or conceive on clomiphene citrate (CC). OBJECTIVES: To compare the effectiveness and safety of gonadotrophins as a second-line treat...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD010290.pub2

データ提供：米国国立医学図書館（NLM）

Gonadotrophins: A Second-Line Treatment for PCOS?

Polycystic ovary syndrome (PCOS) is a common hormonal disorder that can affect fertility. This study examines the effectiveness and safety of gonadotrophins as a second-line treatment for ovulation induction in women with PCOS who do not respond to clomiphene citrate (CC). The researchers conducted a systematic review of randomized controlled trials, comparing the outcomes of using different types of gonadotrophins, including follicle stimulating hormone (FSH) and human menopausal gonadotropin (HMG). Their findings offer valuable insights into the efficacy and safety of gonadotrophins for treating PCOS-related infertility.

Gonadotrophins: A Mixed Bag for PCOS Treatment

The study reveals no significant differences in live birth rates and rates of ovarian hyperstimulation syndrome (OHSS) between urinary-derived gonadotrophins and recombinant FSH (rFSH) or HMG. These findings suggest that both types of gonadotrophins may offer comparable effectiveness and safety for ovulation induction in women with PCOS. However, the study acknowledges the low quality of the evidence, emphasizing the need for further research to clarify the optimal use of these drugs in PCOS treatment.

Navigating the Terrain of PCOS Treatment

This study provides valuable information for women with PCOS who are struggling with infertility. It highlights the potential of gonadotrophins as a viable second-line treatment option, while emphasizing the importance of carefully considering the individual needs and risks associated with each type of gonadotrophin. Further research is needed to refine the use of gonadotrophins for PCOS treatment and to develop more effective and personalized approaches to managing this complex condition.

Dr.Camel's Conclusion

Imagine a vast desert landscape, where a traveler must navigate treacherous dunes and scorching heat. PCOS is like a challenging oasis, where fertility can be elusive. This research explores the use of gonadotrophins, a type of treatment, as a potential path to conception. The findings suggest that different types of gonadotrophins may offer comparable outcomes, but further research is needed to refine their use and ensure safe and effective treatment for women with PCOS.

Date :
  1. Date Completed 2016-03-31
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

26350625

DOI: Digital Object Identifier

10.1002/14651858.CD010290.pub2

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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