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Cost-Effectiveness Analysis of Alternative Antiviral Strategies for the Treatment of HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B in the United Kingdom.

Author: BerminghamSarah L, BoxallElizabeth, DusheikoGeoff, FenuElisabetta, Hill-CawthorneGrant, HughesRalph, SawyerLaura M, T KennedyPatrick, ThomasHoward

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

Pegylated interferon alpha-2a (peg-IFN α-2a) followed by tenofovir disoproxil fumarate or entecavir is the most effective and cost-effective treatment strategy for chronic hepatitis B (CHB).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Seven drugs are licensed for the treatment of chronic hepatitis B (CHB) in the United Kingdom. Which initial treatment, secondary therapy, and whether antivirals should be given alone or in combination are questions of considerable uncertainty. OBJECTIVE: The aim of this model was to un...See full text at original site
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引用元：
https://doi.org/10.1016/j.jval.2015.05.007

データ提供：米国国立医学図書館（NLM）

Cost-Effective Strategies for Chronic Hepatitis B

Chronic hepatitis B (CHB) presents a significant challenge in the [healthcare] field. This research delves into the cost-effectiveness of various antiviral treatments for CHB, aiming to find the most efficient therapeutic sequence. Like a wise camel navigating a vast desert of treatment options, this study utilizes a probabilistic Markov model to analyze the cost-effectiveness of all clinically relevant antiviral treatment sequences for adults with CHB. The researchers compared the effectiveness of different antiviral treatments, including pegylated interferon alpha-2a (peg-IFN α-2a), tenofovir disoproxil fumarate, and entecavir, across different patient groups.

Optimal Treatment Sequences for Chronic Hepatitis B

The study revealed that peg-IFN α-2a followed by tenofovir disoproxil fumarate was the most cost-effective strategy for patients with HBeAg-positive CHB. Similarly, peg-IFN α-2a followed by entecavir emerged as the most cost-effective treatment for HBeAg-negative CHB patients. These findings highlight the potential for tailored treatment approaches based on patient characteristics.

Cost-Effective Treatment for Chronic Hepatitis B

The results suggest that these cost-effective treatment strategies offer a promising path toward improving the management of CHB. With a cost of less than £10,000 per QALY gained, these sequences are considered cost-effective in England and Wales. This study provides valuable insights for healthcare professionals seeking to optimize the management of CHB, ensuring that patients receive the most effective and cost-effective treatments.

Dr. Camel's Conclusion

This research is like a compass guiding us through the vast desert of CHB treatment options. It provides valuable insights into the optimal treatment sequences for different patient groups. However, it's important to note that these findings should be considered in conjunction with individual patient factors and clinical judgment.

Date :
  1. Date Completed 2016-01-08
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

26409607

DOI: Digital Object Identifier

10.1016/j.jval.2015.05.007

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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