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Clinical pharmacology of atypical antipsychotics: an update.

Author: AltamuraA C, ColasantiA, Di PaceC, DragognaF, MaffiniM, MauriM C, PalettaS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review summarizes the clinical pharmacology and pharmacodynamic data related to atypical antipsychotics, including clozapine, risperidone, paliperidone, olanzapine, quetiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. It also provides a summary of their acute pharmacokinetic properties. Four new second-generation antipsychotics are available: iloperidone, asenapine, lurasidone and in the next future cariprazine. These new agents are advisable for the lower propensity to give weight gain and metabolic abnormalities compared with older second-generation antipsychotics. Lurasidone seems to be best in terms of minimizing unwanted alterations in body weight and metabolic variables. Therapeutic drug monitoring is not strictly necessary for all of the new antipsychotic drugs because there are no unequivocal data supporting a relationship between plasma drug levels and clinical outcomes or side effects. The exception can be represented by clozapine for which plasma levels of 350-420 ng/ml are reported to be associated with an increased probability of a good clinical response. Also for olanzapine an established therapeutic range (20-50 ng/ml) is proposed to yield an optimal response and minimize side effects.
Paper Details　
Original Abstract of the Article :
This review will concentrate on the clinical pharmacology, in particular pharmacodynamic data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine, que¬tiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. A summary of t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464358/

データ提供：米国国立医学図書館（NLM）

Atypical Antipsychotics: Navigating the Desert of Mental Health

Mental illness is a vast and often misunderstood desert, leaving many individuals feeling lost and alone. This research provides a comprehensive overview of atypical antipsychotics, a class of medications used to treat various mental health conditions. The authors delve into the clinical pharmacology and pharmacodynamic properties of several atypical antipsychotics, including their effectiveness, side effects, and therapeutic ranges. They highlight the importance of careful monitoring and individualized treatment approaches, emphasizing the need to find the right oasis of care for each patient.

Atypical Antipsychotics: A Diverse Oasis in the Desert of Mental Health

This research explores the diverse landscape of atypical antipsychotics, offering a detailed look at the various medications available for treating mental health conditions. The authors emphasize the importance of understanding the unique characteristics of each medication, including its effectiveness, side effects, and potential interactions. This information is crucial for healthcare professionals to tailor treatment approaches to the individual needs of each patient, ensuring a more personalized and effective path to recovery.

The Importance of Personalized Care in Mental Health

This research underscores the importance of personalized care in mental health treatment. The authors emphasize that each individual's experience with mental illness is unique, requiring a tailored approach to treatment. By understanding the specific characteristics of each medication and the individual needs of the patient, healthcare professionals can select the most effective treatment plan, maximizing the potential for recovery.

Dr.Camel's Conclusion

This research offers valuable insights into the diverse oasis of atypical antipsychotics, providing a roadmap for navigating the complex desert of mental health. By understanding the unique characteristics of each medication and tailoring treatment approaches to the individual needs of each patient, healthcare professionals can help individuals find their way to recovery and well-being.

Date :
  1. Date Completed 2015-09-29
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

26417330

DOI: Digital Object Identifier

PMC4464358

SNS
PICO Info
in preparation
Languages

English

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