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Nifedipine in the prophylaxis of classic migraine: a crossover, double-masked, placebo-controlled study of headache frequency and side effects.

Author: MarekK, McArthurJ, McArthurJ C, PeroutkaS J, PestronkA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nifedipine, a calcium channel blocker, was evaluated for its effectiveness in treating migraine headaches. Nifedipine did not significantly reduce the frequency of headaches compared to placebo, but it caused significantly more side effects.
Paper Details　
Original Abstract of the Article :
Twenty-four patients with classic migraine attacks were treated with either nifedipine or placebo for up to 12 weeks. No significant differences were observed between the nifedipine (2.1 +/- 0.2) and placebo (2.3 +/- 0.2) treatment groups in the monthly frequency of headaches. However, the incidence...See full text at original site
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引用元：
https://doi.org/10.1212/wnl.39.2.284

データ提供：米国国立医学図書館（NLM）

Nifedipine for Migraine Prevention: A Double-Masked Crossover Study

Migraines are a common and debilitating condition, affecting millions worldwide. This study investigates the efficacy of nifedipine, a calcium channel blocker, in preventing classic migraine attacks. The researchers employed a double-masked, crossover design, allowing them to compare the effects of nifedipine against a placebo.

Nifedipine's Impact on Migraine Frequency

While nifedipine did not significantly reduce the frequency of migraine attacks compared to the placebo, it did lead to a significantly higher incidence of side effects. These findings highlight the potential trade-offs associated with using nifedipine for migraine prevention. The researchers reported a statistically significant difference in the incidence of side effects, suggesting a need for careful consideration of the potential risks and benefits of this treatment approach.

Navigating the Sands of Migraine: A Camel's Perspective

Migraines can feel like a desert storm, a relentless force that disrupts your life. Just as a desert traveler must navigate treacherous sand dunes, migraine sufferers seek relief from the intense pain and discomfort. This research highlights the importance of carefully weighing the potential benefits and risks of different migraine treatment options, akin to choosing the safest path through the desert.

Dr.Camel's Conclusion

While nifedipine did not demonstrate significant efficacy in reducing migraine frequency, the study underscores the importance of considering the potential side effects of any treatment. Further research is needed to explore more effective and tolerable migraine prevention strategies.

Date :
  1. Date Completed 1989-03-23
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

2644581

DOI: Digital Object Identifier

10.1212/wnl.39.2.284

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Article Analysis
・Side Effects of nifedipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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