Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.

Author: ChenMei-Wan, ChenYao, ChengKe-Jun, JiangQi-Wei, LvMin, MeiXiao-Long, QinWu-Ming, QiuJian-Ge, ShiZhi, WeiMeng-Ning, WeiXing, XueYou-Qiu, YangYang, ZhangWen-Ji, ZhangXu, ZhengDi-Wei

Paper Details 
Original Abstract of the Article :
Triptolide and celastrol are two main active compounds isolated from Thunder God Vine with the potent anticancer activity. However, the anticancer effect of triptolide in combination with celastrol is still unknown. In the present study, we demonstrated that the combination of triptolide with celast...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741730/

データ提供:米国国立医学図書館(NLM)

Triptolide and Celastrol: A Synergistic Duo Against Cancer

Cancer, a formidable foe, can feel like an unforgiving desert, demanding relentless search for effective treatments. This research, like a team of scientists working tirelessly to develop new weapons against cancer, investigates the synergistic anticancer effects of triptolide and celastrol, two potent compounds extracted from Thunder God Vine. The researchers, like skilled alchemists blending potent ingredients, discovered that the combination of triptolide and celastrol synergistically inhibited cancer cell growth, induced cell cycle arrest, and promoted apoptosis. They observed that the combination of these two compounds significantly increased intracellular reactive oxygen species (ROS) accumulation, contributing to the observed anticancer effects. Furthermore, they demonstrated that the combination of triptolide and celastrol effectively inhibited tumor growth in mice models, highlighting its potential as a promising new anticancer therapy.

A Synergistic Assault: Triptolide and Celastrol Team Up Against Cancer

This research unveils the potent synergistic anticancer effects of triptolide and celastrol. The combination of these two compounds demonstrates significant anti-cancer activity, offering a potential new strategy for treating this devastating disease. The study's findings provide a compelling case for further investigation into the therapeutic potential of this synergistic combination.

Fighting Cancer in the Desert: A Journey of Hope

This research offers a glimmer of hope in the fight against cancer. The synergistic anticancer effects of triptolide and celastrol represent a potential breakthrough in cancer treatment. While further research is needed to fully understand the efficacy and safety of this combination, it offers a promising avenue for developing novel cancer therapies. Remember, like a resilient desert plant weathering the harsh conditions, we must persevere in our search for effective cancer treatments.

Dr.Camel's Conclusion

This study provides compelling evidence for the synergistic anticancer effects of triptolide and celastrol. The combination of these two compounds demonstrates significant anti-cancer activity, offering a promising new strategy for treating this devastating disease.
Date :
  1. Date Completed 2016-08-09
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

26447544

DOI: Digital Object Identifier

PMC4741730

Related Literature

SNS
PICO Info
in preparation
Languages

English

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