[Comparative double-blind study of the effectiveness and tolerance of baclofen, tetrazepam and tizanidine in spastic movement disorders of the lower extremities].

Author: PauligM, PellkoferM

Paper Details 
Original Abstract of the Article :
In a double-blind comparative study, the therapeutic efficacy and safety of three centrally effective antispasmodics (Tetrazepam, Baclofen and Tizanidine) in patients suffering from multiple sclerosis with spastic motor disturbances of the lower extremities was to be examined. 47 patients of either ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2645508

データ提供:米国国立医学図書館(NLM)

Comparative Double-Blind Study of Baclofen, Tetrazepam, and Tizanidine in Spastic Movement Disorders

This research investigates the efficacy and safety of three centrally effective antispasmodics: Tetrazepam, Baclofen, and Tizanidine, in patients with spastic movement disorders of the lower extremities. The study, a [double-blind comparative trial] involving [47 patients with multiple sclerosis], aimed to compare the effectiveness of these drugs in reducing spasticity and improving mobility. The authors found that all three drugs showed comparable reductions in muscle tone, but Tetrazepam demonstrated the most favorable benefit/risk ratio in terms of side effects.

Tetrazepam Emerges as a Favorable Antispasmodic Option

The study highlights Tetrazepam's potential as a safe and effective antispasmodic agent for treating spastic movement disorders in patients with multiple sclerosis. The researchers found that Tetrazepam offered a comparable level of efficacy to other antispasmodics while exhibiting a more favorable side effect profile. This finding suggests that Tetrazepam could be a valuable option for patients seeking relief from spasticity while minimizing the risk of adverse effects. It's like finding a path through a desert that offers a clear and safe passage, minimizing the risk of encountering harsh conditions.

Navigating Spasticity with Antispasmodics

This research provides valuable insights into the treatment of spastic movement disorders. It highlights the importance of carefully considering the individual patient's needs and choosing the most appropriate antispasmodic based on efficacy and safety profiles. It's like choosing the right camel for a desert journey – the journey may be long and challenging, but with the right companion, we can navigate the terrain safely and comfortably.

Dr. Camel's Conclusion

This study emphasizes the importance of choosing the right antispasmodic for treating spastic movement disorders, balancing efficacy with safety. The findings suggest that Tetrazepam may be a favorable option for patients with multiple sclerosis, offering a comparable level of efficacy with a more favorable side effect profile. It's like finding a hidden oasis in the desert – a place of relief and healing for those battling the challenges of spasticity.

Date :
  1. Date Completed 1989-03-30
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

2645508

DOI: Digital Object Identifier

2645508

Related Literature

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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