Fc receptors and their influence on efficacy of therapeutic antibodies for treatment of viral diseases.

Author: ChanKuan Rong, MokDarren Z L, OngEugenia Z, OoiEng Eong

Paper Details 
Original Abstract of the Article :
The lack of vaccines against several important viral diseases necessitates the development of therapeutics to save lives and control epidemics. In recent years, therapeutic antibodies have received considerable attention due to their good safety profiles and clinical success when used against viruse...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673539/

データ提供:米国国立医学図書館(NLM)

Fc Receptors: A Key to Therapeutic Antibody Efficacy

The field of [immunology] is constantly seeking ways to harness the power of the immune system to combat disease. This study delves into the critical role of [Fc receptors] in determining the effectiveness of [therapeutic antibodies] for the treatment of [viral diseases]. The researchers highlight the importance of considering both the [binding affinity] of antibodies and the subtype of [Fc-gamma receptors (FcγRs)] engaged in the therapeutic process. They emphasize that the engagement of different FcγR subtypes can influence the stoichiometric requirement for [virus neutralization]. This research provides valuable insights for the development of more effective and targeted therapeutic antibodies for viral infections.

A Deeper Understanding of FcγR Engagement for Improved Antibody Therapies

This study underscores the importance of understanding the [Fc-FcγR interactions] involved in [virus neutralization]. The findings suggest that the development of therapeutic antibodies should take into account the specific FcγR subtypes engaged and the associated effector functions. This approach could lead to the development of more effective and targeted therapies for [viral infections]. The study also highlights the need for further research to optimize antibody design and ensure that therapies are tailored to the specific needs of each patient.

Health Implications and Lifestyle Applications

This research offers hope for the development of more effective [therapeutic antibodies] for the treatment of [viral infections]. Individuals with [viral infections] should continue to follow the recommended treatment guidelines provided by their healthcare providers. Further research in this area is essential for developing more effective and targeted therapies to combat viral diseases.

Dr.Camel's Conclusion

The quest for effective [therapeutic antibodies] is like a caravan traversing a vast and intricate desert landscape. This study illuminates the importance of understanding the interplay between antibodies and FcγRs, providing valuable insights for optimizing antibody design and ensuring maximum therapeutic efficacy. As we continue our journey through the sands of scientific discovery, we eagerly anticipate future breakthroughs that may lead to more effective therapies for viral infections.

Date :
  1. Date Completed 2016-07-29
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26466016

DOI: Digital Object Identifier

PMC4673539

SNS
PICO Info
in preparation
Languages

English

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