Paper Details

  1. Home
  2. Paper Details

Predictive Value of Retinal Morphology for Visual Acuity Outcomes of Different Ranibizumab Treatment Regimens for Neovascular AMD.

Author: MargaronPhilippe, Schmidt-ErfurthUrsula, SimaderChristian, WaldsteinSebastian M, WarburtonJames, WrightJonathan

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Patients with neovascular age-related macular degeneration (nAMD) who have both subretinal fluid (SRF) and posterior vitreous detachment (PVD) at baseline may require less frequent treatments compared with patients without SRF or PVD.
Paper Details　
Original Abstract of the Article :
PURPOSE: To establish the predictive value of defined retinal morphologic parameters on visual outcomes and re-treatment needs in patients with neovascular age-related macular degeneration (nAMD) receiving ranibizumab treatment. DESIGN: Post hoc analysis of a prospective, 12-month, multicenter, pha...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ophtha.2015.09.013

データ提供：米国国立医学図書館（NLM）

Unveiling the Secrets of Neovascular AMD: A Desert of Delicate Structures

Neovascular age-related macular degeneration (nAMD) is a complex condition, a desert of delicate retinal structures under threat. This study delves into the intricacies of nAMD, exploring the predictive value of retinal morphology in guiding treatment strategies.

The researchers analyzed data from 319 patients with nAMD who received ranibizumab treatment, focusing on the relationship between baseline retinal morphology and visual outcomes. Their findings offer valuable insights into the interconnectedness of retinal structure and function, like deciphering the patterns of sand dunes in a vast desert.

Tailoring Ranibizumab Treatment Based on Retinal Morphology

The study revealed that specific retinal morphologic parameters, such as the presence of subretinal fluid and posterior vitreous detachment, are strong predictors of visual outcomes and re-treatment needs. It's like understanding the interplay of water and sand in a desert oasis, recognizing how specific features impact the overall ecosystem.

Personalized Treatment Strategies for NAMD

This study provides a roadmap for personalized treatment strategies in nAMD, allowing for more targeted and effective interventions based on individual retinal morphology. It's like creating a custom irrigation system for a desert oasis, maximizing water use and promoting healthy growth.

Dr. Camel's Conclusion

This study provides a comprehensive understanding of the role of retinal morphology in predicting visual outcomes and re-treatment needs in nAMD. It's like discovering a hidden map in the desert, guiding us towards more effective and personalized treatment strategies.

Date :
  1. Date Completed 2016-04-26
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

26481821

DOI: Digital Object Identifier

10.1016/j.ophtha.2015.09.013

Related Literature

Article Analysis
・Effective treatment of macular degeneration
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.