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Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.

Author: , DorosGheorghe, FuhlbriggeAnne L, IsraelElliot, KazaniShamsah, LanzillottiJane, MadisonSuzanne, PaceWilson D, PencinaMichael J, RabyBenjamin A, WechslerMichael E, YawnBarbara P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study found that adding a long-acting β-agonist (LABA) to inhaled corticosteroids did not improve asthma control in black adults with asthma compared with adding tiotropium.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: The efficacy and safety of long-acting β-agonists (LABAs) have been questioned. Black populations may be disproportionately affected by LABA risks. OBJECTIVE: To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults wit...See full text at original site
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引用元：
https://doi.org/10.1001/jama.2015.13277

データ提供：米国国立医学図書館（NLM）

Anticholinergics vs. Long-Acting β-Agonists: A Tale of Two Asthma Treatments

The field of [Asthma Management] is always searching for the best treatments for diverse patient populations. This study, the BELT Randomized Clinical Trial, focuses on the effectiveness and safety of tiotropium (an anticholinergic) and long-acting β-agonists (LABAs) in combination with inhaled corticosteroids (ICS) in black adults with asthma. The study found no significant differences in time to asthma exacerbation, lung function, or patient-reported outcomes between the two treatment groups. Furthermore, the study found no association between allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) gene and treatment response. These findings suggest that tiotropium may be a viable alternative to LABAs for black adults with asthma.

Tiotropium: A Promising Alternative for Asthma Control

This study offers valuable insights into the treatment of asthma in black adults, demonstrating that tiotropium may be an effective alternative to LABAs. The study's findings could lead to improved asthma management and better outcomes for black patients.

Tailoring Asthma Treatment: A Personalized Approach

This research highlights the importance of tailoring asthma treatment to individual needs. The study's findings demonstrate that tiotropium may be a suitable alternative to LABAs for black adults with asthma.

Dr. Camel's Conclusion

Asthma treatment is a journey through a vast and complex desert. This study explores the landscape of treatment options, finding that tiotropium may offer a valuable path for black adults with asthma. By understanding the nuances of asthma and considering individual needs, we can guide patients toward better control and improved quality of life.

Date :
  1. Date Completed 2015-11-10
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

26505596

DOI: Digital Object Identifier

10.1001/jama.2015.13277

Related Literature

Article Analysis
・Effects of tiotropium oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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