Effects of tiotropium oral inhalation: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Major Research Findings

Tiotropium, a long-acting muscarinic antagonist (LAMA), has shown promise in treating asthma, particularly in patients whose condition remains uncontrolled despite conventional therapies. 9 , 11 Tiotropium works by relaxing the muscles in the airways, making it easier to breathe. 8 It has demonstrated effectiveness in improving lung function, especially in adults. 11 Research suggests that tiotropium may also reduce the frequency of asthma exacerbations, which are periods of worsening symptoms. 11 However, more studies are needed to definitively determine its benefit in asthma management. 11 Tiotropium's safety profile appears to be favorable, with similar rates of adverse events compared to placebo in a large clinical trial involving over 6,000 patients. 4 Side effects typically associated with anticholinergic drugs, such as dry mouth, were reported infrequently. 4

Benefits and Risks

Benefit Summary

Tiotropium offers potential benefits for asthma management, including improved lung function, reduced exacerbation frequency, and a generally safe profile. 9 11 4 It could be a valuable option for patients struggling to control their asthma symptoms with conventional therapies.

Risk Summary

While tiotropium has shown a good safety profile, it can cause some side effects, such as dry mouth. 4 These side effects are usually mild and not experienced by everyone.

Comparison Across Studies

Commonalities in Studies

Multiple studies have indicated that tiotropium can be beneficial in managing asthma, especially for adults. 9 11 12 4 Tiotropium has emerged as a promising option for patients with uncontrolled asthma.

Differences in Studies

The methods used to assess tiotropium's effectiveness and safety varied across studies. 9 11 12 4 As a result, directly comparing findings requires caution. While tiotropium appears to have a positive effect on lung function, further research is necessary to determine its precise role in asthma management.

Consistency and Contradictions in Findings

Several studies have shown that tiotropium can be beneficial in managing asthma, particularly for adults. 9 11 12 4 However, some studies have not definitively established its benefit in asthma management. 12 It is important to remember that tiotropium may not be effective for every individual with asthma. 12

Implications for Real-World Application

Tiotropium may be prescribed by your doctor as a treatment option for asthma. 9 11 If you are taking tiotropium, follow your doctor's instructions carefully. 9 11 Tiotropium may not be effective for everyone, and it is crucial to consult with your doctor to determine if it is the right treatment for you.

Limitations of Current Research

While studies have shown promising results, more research is needed to fully understand tiotropium's long-term effectiveness and safety, especially in children. 9 11 12 4

Future Research Directions

Further research is warranted to explore tiotropium's long-term effects and safety, especially in children. 9 11 12 4 More research is needed to definitively determine its role in asthma management.

Conclusion

Tiotropium holds potential as a treatment option for asthma, particularly for those whose symptoms remain uncontrolled with conventional therapies. 9 11 4 However, not everyone with asthma will respond to tiotropium. 12 It is essential to consult with your doctor to determine if tiotropium is the right treatment for you. 9 11 4

Literature analysis of 12 papers
Positive Content
11
Neutral Content
1
Negative Content
0
Article Type
5
3
4
7
12
1.

Tinidazole vs metronidazole for the treatment of bacterial vaginosis.

Author: SchwebkeJane R, DesmondRenee A

Bacterial vaginosis treatment
Side effects

Tinidazole was as effective as metronidazole in treating bacterial vaginosis. In a randomized controlled trial involving 593 women, there were no significant differences in cure rates between metronidazole and tinidazole, regardless of the dosage used.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Tiotropium Bromide Attenuates Mucus Hypersecretion in Patients with Stable Chronic Obstructive Pulmonary Disease.

Author: YuSuyun, ZhangCaili, YanZhijun, FangQingqing, GaoXiwen

COPD treatment
Mucus hypersecretion
Tiotropium bromide

This study investigated the effect of tiotropium bromide on sputum and sputum viscosity in patients with stable chronic obstructive pulmonary disease (COPD). The study found that tiotropium bromide did not significantly affect sputum volume or viscosity, suggesting that it may not have a direct effect on mucus hypersecretion in COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A comparison of tiotropium, long-acting &#946;<sub>2</sub>-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma.

Author: VogelbergChristian, GoldsteinStanley, GrahamLeRoy, KaplanAlan, de la HozAlberto, HamelmannEckard

Asthma Control

This literature review compares the efficacy and safety of long-acting β2-agonists (LABAs), leukotriene receptor antagonists (LTRAs), and long-acting muscarinic antagonists (LAMAs) as add-on treatments to inhaled corticosteroids (ICS) in children and adolescents with asthma. The review concludes that tiotropium and LABAs are more effective than LTRAs and have comparable safety profiles.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Safety of tiotropium in patients with asthma.

Author: DusserDaniel, DucharmeFrancine M

Asthma control
Safety and tolerability
Asthma worsening
Decreased peak expiratory flow
Upper respiratory tract infections

Tiotropium, a drug used to treat asthma, has a good safety profile in adults and children, with similar rates of adverse events in different ethnic groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Once-daily long-acting beta₂-agonists/inhaled corticosteroids combined inhalers versus inhaled long-acting muscarinic antagonists for people with chronic obstructive pulmonary disease.

Author: SliwkaAgnieszka, JankowskiMilosz, Gross-SondejIwona, StormanMonika, NowobilskiRoman, BalaMalgorzata M

COPD Treatment
Patient Adherence

Combining long-acting beta₂-agonists (LABA) and long-acting muscarinic antagonists (LAMA) in a single inhaler device provides convenient once-daily dosing for managing chronic obstructive pulmonary disease (COPD), potentially improving patient adherence to treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Controlling the Risk Domain in Pediatric Asthma through Personalized Care.

Author: AndersonWilliam C, SzeflerStanley J

Asthma control
Asthma treatment
Asthma exacerbations
Lung growth reduction

This review highlights the importance of controlling asthma exacerbations, reducing lung growth reduction, and managing treatment-related adverse effects in children and adolescents with asthma. It explores the use of biomarkers and new therapies like tiotropium, omalizumab, and macrolide antibiotics to personalize asthma management in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Safety and tolerability of once-daily tiotropium Respimat(®) as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: A pooled safety analysis.

Author: DahlRonald, EngelMichael, DusserDaniel, HalpinDavid, KerstjensHuib A M, Zaremba-PechmannLiliana, Moroni-ZentgrafPetra, BusseWilliam W, BatemanEric D

Cardiac disorders
Dry mouth

Tiotropium delivered via the Respimat device was found to be safe and well-tolerated as add-on therapy to inhaled corticosteroids (ICS) in patients with symptomatic asthma. The study pooled data from seven trials involving 3,474 patients. The incidence of adverse events, including serious adverse events, was comparable between tiotropium and placebo groups.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Long-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma.

Author: KewKayleigh M, DahriKaren

Asthma treatment

Combination medications for asthma, like long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS), can help control symptoms and reduce flare-ups. However, some people don't achieve good control with these medications. A new type of inhaler, long-acting muscarinic antagonists (LAMA), used successfully for lung disease, is now being used for asthma alongside LABA/ICS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.

Author: WechslerMichael E, YawnBarbara P, FuhlbriggeAnne L, PaceWilson D, PencinaMichael J, DorosGheorghe, KazaniShamsah, RabyBenjamin A, LanzillottiJane, MadisonSuzanne, IsraelElliot,

Asthma exacerbation

This study found that adding a long-acting β-agonist (LABA) to inhaled corticosteroids did not improve asthma control in black adults with asthma compared with adding tiotropium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthma.

Author: AndersonDebbie E, KewKayleigh M, BoyterAnne C

LAMA for asthma

This research investigates the potential benefits of long-acting muscarinic antagonists (LAMAs) for treating asthma. Previous studies have shown promising results for LAMAs, but more research is needed to confirm their efficacy and determine the optimal place for LAMAs in asthma management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults with asthma.

Author: EvansDavid J W, KewKayleigh M, AndersonDebbie E, BoyterAnne C

Alternative to higher ICS doses
Effective COPD treatment
Undesirable side effects

Long-acting muscarinic antagonists (LAMA) may be a safe and effective add-on option for adults with asthma who are uncontrolled on inhaled corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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