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The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review.

Author: NielsenJimmi, PolcwiartekChristoffer

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study reviews the pharmacodynamic effects and adverse effect profile of changing the clozapine/N-desmethylclozapine (NDMC) ratio with adjunctive fluvoxamine. Evidence supports that adjunctive fluvoxamine increases clozapine plasma levels, which may improve response in patients who do not achieve sufficient clozapine levels. Fluvoxamine also reduces metabolic adverse effects of clozapine, but not agranulocytosis risk.
Paper Details　
Original Abstract of the Article :
RATIONALE: New clozapine optimization strategies are warranted, as some patients do not achieve sufficient response and experience various adverse effects. Fluvoxamine is a potent CYP1A2 inhibitor and may increase the ratio of clozapine to its primary metabolite N-desmethylclozapine (NDMC). OBJECTI...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-015-4161-1

データ提供：米国国立医学図書館（NLM）

Fluvoxamine: A Potential Oasis for Clozapine Optimization

Imagine the intricate process of treating schizophrenia as a vast desert landscape, with various therapeutic strategies offering potential oases of relief. This study explores the potential of adjunctive fluvoxamine, a serotonin reuptake inhibitor, to optimize the effectiveness of clozapine, a powerful antipsychotic medication, in individuals with schizophrenia. The researchers delve into the pharmacodynamic effects of fluvoxamine on clozapine metabolism, highlighting its ability to inhibit the enzyme CYP1A2, leading to increased levels of clozapine in the bloodstream. They review the potential benefits of this approach, including improved therapeutic response and reduced metabolic adverse effects of clozapine.

A New Path to Optimal Treatment

The study suggests that adjunctive fluvoxamine, like a strategic oasis in the desert, could potentially enhance the effectiveness of clozapine treatment, leading to improved patient outcomes and potentially reducing the risk of metabolic complications.

Navigating the Desert of Challenges

The authors acknowledge that further research is needed to fully understand the implications of adjunctive fluvoxamine. They emphasize the importance of carefully monitoring patients for potential side effects and tailoring treatment strategies to individual needs.

Dr. Camel's Conclusion

The desert of schizophrenia treatment is complex and often challenging. This study explores the potential of adjunctive fluvoxamine as a valuable tool for optimizing clozapine therapy. While further research is needed to confirm its benefits and guide its safe and effective use, the findings suggest that this approach could offer a new oasis of hope for individuals seeking optimal treatment for this complex condition.

Date :
  1. Date Completed 2016-09-30
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26626327

DOI: Digital Object Identifier

10.1007/s00213-015-4161-1

SNS
PICO Info
in preparation
Languages

English

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