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Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis.

Author: , AbitbolVered, AllezMathieu, BommelaerGilles, BossaFabrizio, BouhnikYoram, BourreilleArnaud, BrixiHedia, CarbonnelFranck, ColombelJean Frédéric, CoulibalyBaya, DaneseSilvio, DeplanqueDominique, DewitOlivier, FilippiJérome, FumeryMathurin, FärkkiläMartti, KatsanosKonstantinos H, LaharieDavid, LouisEdouard, MalamutGeorgia, MichettiPierre, MoreauJacques, NachuryMaria, NovacekGottfried, Peyrin-BirouletLaurent, ReinischWalter, RoblinXavier, SarterHélène, SeksikPhilippe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized controlled trial evaluated the safety and efficacy of parenteral methotrexate for treating steroid-dependent ulcerative colitis (UC). While methotrexate did not demonstrate superiority to placebo in inducing steroid-free remission, it did induce clinical remission without steroids in a significantly larger proportion of patients.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: Parenteral methotrexate is an effective treatment for patients with Crohn's disease, but has never been adequately evaluated in patients with ulcerative colitis (UC). We conducted a randomized controlled trial to determine its safety and efficacy in patients with steroid-dependent...See full text at original site
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引用元：
https://doi.org/10.1053/j.gastro.2015.10.050

データ提供：米国国立医学図書館（NLM）

Methotrexate for Ulcerative Colitis: A New Frontier

Ulcerative colitis, a chronic inflammatory bowel disease, can have a significant impact on a person's life. This research examines the efficacy of methotrexate, a drug commonly used for Crohn's disease, as a treatment for ulcerative colitis. The study, conducted across multiple medical centers in Europe, compared the effects of parenteral methotrexate to a placebo in patients with corticosteroid-dependent ulcerative colitis. The primary aim was to determine whether methotrexate could induce steroid-free remission in these patients.

Methotrexate Shows Promise in Ulcerative Colitis

The results of the study show that while methotrexate was not superior to placebo in achieving complete steroid-free remission, it did significantly improve clinical remission. It's like a desert traveler finding a patch of fertile ground in a barren landscape. The researchers found that a larger proportion of patients treated with methotrexate achieved clinical remission without the need for steroids. This finding suggests that methotrexate may play a valuable role in managing ulcerative colitis, especially for individuals who rely on corticosteroids for symptom control.

Potential Benefits and Considerations

The study provides valuable insights into the potential benefits of methotrexate as a treatment for ulcerative colitis. However, it is important to note that more research is needed to fully understand the long-term effects of methotrexate in this context. The study also highlights the importance of carefully monitoring patients treated with methotrexate for potential side effects, such as nausea and vomiting.

Dr.Camel's Conclusion

This research sheds light on the potential of methotrexate in managing ulcerative colitis. Like a desert explorer carefully navigating a new and unknown territory, this study provides valuable insights into the potential benefits and challenges of using methotrexate for ulcerative colitis. The findings offer hope for patients seeking alternative treatment options and highlight the need for continued research to fully understand the role of methotrexate in the management of inflammatory bowel diseases.

Date :
  1. Date Completed 2016-06-03
  2. Date Revised 2018-04-02
Further Info :

Pubmed ID

26632520

DOI: Digital Object Identifier

10.1053/j.gastro.2015.10.050

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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