The safety and efficacy of Avanafil, a new 2(nd) generation PDE5i: comprehensive review and meta-analysis.

Author: BurriAndrea, CoronaGiovanni, JanniniEmmanuele A, MaggiMario, RastrelliGiulia

Paper Details 
Original Abstract of the Article :
INTRODUCTION: The discontinuation rate with phosphodiesterase type 5 inhibitors (PDE5i) remains very high. Recently, a new PDE5ì, avanafil, has become available worldwide. AREAS COVERED: All placebo-controlled randomized clinical trials (RCTs) on the effect of avanafil in patients with ED were revi...See full text at original site
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引用元:
https://doi.org/10.1517/14740338.2016.1130126

データ提供:米国国立医学図書館(NLM)

Avanafil: A New Dawn in the Desert of Erectile Dysfunction

Erectile dysfunction (ED), a common condition that can significantly impact a man's quality of life, has long been a focus of medical research. Phosphodiesterase type 5 inhibitors (PDE5is), such as sildenafil and tadalafil, have become mainstay treatments for ED, but some men experience side effects or lack of efficacy with these medications. This study, my fellow researchers, examines the safety and efficacy of avanafil, a new generation PDE5i, offering a potential solution to address these challenges. The authors conducted a meta-analysis of clinical trials comparing avanafil to placebo, revealing its superior efficacy in achieving successful sexual intercourse. They also found that avanafil is well tolerated, with a lower incidence of side effects compared to first-generation PDE5is. These findings suggest that avanafil holds promise as a safe and effective treatment option for ED.

A New Oasis in the Desert of ED: Avanafil

This meta-analysis provides compelling evidence for the safety and efficacy of avanafil, a new generation PDE5i, highlighting its potential as a valuable treatment option for ED. The study's findings suggest that avanafil offers a viable alternative to existing treatments, addressing the limitations of first-generation PDE5is.

Navigating the Desert of Intimacy: Seeking Solutions for ED

The desert of intimacy can be a challenging and often uncomfortable place for men experiencing ED. As Dr. Camel, I’ve learned that navigating this terrain requires understanding and support. This research offers a glimmer of hope, providing a potential new solution to address this common and often sensitive condition.

Dr.Camel's Conclusion

This meta-analysis provides strong evidence for the efficacy and safety of avanafil, a new generation PDE5i, suggesting that it holds promise as a valuable treatment option for ED.

Date :
  1. Date Completed 2016-10-07
  2. Date Revised 2022-04-19
Further Info :

Pubmed ID

26646748

DOI: Digital Object Identifier

10.1517/14740338.2016.1130126

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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