Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus).

Author: ChenWei, HouKangkang, LuGuanghua, QinDonghong, XieZhengxin, YanZhenhua

Paper Details 
Original Abstract of the Article :
Diphenhydramine (DPH), an antihistamine used to alleviate human allergies, is widespread in aquatic environments. However, little is known about the biochemical and behavioral effects of DPH on non-target aquatic animals. In the present study, the tissue distribution, bioconcentration, metabolism, b...See full text at original site
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引用元:
https://doi.org/10.1016/j.scitotenv.2015.11.132

データ提供:米国国立医学図書館(NLM)

The Impact of Diphenhydramine on Crucian Carp

This research explores the impact of diphenhydramine, a common antihistamine, on crucian carp, a type of fish. It’s a fascinating study as it delves into the intricate world of drug interactions in aquatic environments. To unravel this mystery, the researchers used various concentrations of diphenhydramine and observed its effects on the fish. Their findings revealed that diphenhydramine can accumulate in crucian carp, particularly in the liver and brain, with the highest concentrations found in these organs. This accumulation was further investigated by examining the metabolic processes within the fish. The researchers discovered that crucian carp can metabolize diphenhydramine, breaking it down into smaller molecules. This process, however, can be a double-edged sword, leading to changes in the fish's behavior. It was discovered that exposure to diphenhydramine can affect the fish's swimming patterns, feeding behavior, and social interactions. For example, the fish exhibited increased shoaling behavior, which is a way for them to gather in groups, while their swimming activity and appetite decreased. This research highlights the complex interplay between environmental pollutants and aquatic life. It suggests that even seemingly benign substances like antihistamines, when introduced into the environment, can have unintended consequences. This research provides valuable insights into the impact of pharmaceuticals on the health of aquatic ecosystems.

Diphenhydramine’s Potential to Disrupt Aquatic Ecosystems

The study concluded that diphenhydramine can accumulate and be metabolized in fish, potentially impacting their health and behavior. These findings are crucial for understanding the broader environmental implications of pharmaceuticals and highlight the need for responsible drug disposal and waste management practices. The research revealed that even at low doses, diphenhydramine can significantly alter the fish's physiology and behavior. For example, the researchers observed a significant increase in oxidative stress levels, which are a sign of cellular damage, in the liver of the fish. These findings underscore the potential for pharmaceuticals to negatively impact aquatic ecosystems.

Navigating the Waters of Pharmaceuticals and Wildlife

These findings underscore the importance of being mindful of the potential impact of pharmaceuticals on the environment. It’s like a ripple in the water, with a seemingly small action having larger consequences. Our actions, like throwing away medications or flushing them down the toilet, can have significant impacts on aquatic ecosystems. This research emphasizes the importance of responsible pharmaceutical disposal and waste management, ensuring that our actions don't unintentionally harm the delicate balance of nature. It's a reminder that even seemingly innocuous substances can have a profound impact on wildlife.

Dr.Camel's Conclusion

This study is a valuable contribution to our understanding of the environmental impact of pharmaceuticals. It serves as a reminder that even seemingly harmless substances can have unintended consequences for wildlife. Like a camel traversing a desert, we need to be aware of the environmental footprint of our actions and ensure that we're not leaving a trail of harmful substances in our wake.

Date :
  1. Date Completed 2016-10-21
  2. Date Revised 2016-12-30
Further Info :

Pubmed ID

26657385

DOI: Digital Object Identifier

10.1016/j.scitotenv.2015.11.132

Related Literature

SNS
PICO Info
in preparation
Languages

English

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