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Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity.

Author: ChoiYoung-Whan, ImDong-Soon, JungJee H, KangSaeromi, KimJung-Min, LeeJung-Min, LeeKyoung-Pil, LeeYoung-Geun, MoonHyung Ryong, ParkSoo-Jin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Petatewalide B, a novel bakkenolide-type sesquiterpine isolated from Petasites japonicus leaves, was found to have anti-allergic and anti-inflammatory effects.
Paper Details　
Original Abstract of the Article :
ETHNOPHARMACOLOGICAL RELEVANCE: The giant butterbur Petasites japonicus is used to treat asthma and allergic diseases in traditional Korean, Japanese, and Chinese medicine. AIM OF THE STUDY: To elucidate the anti-allergic effect of Petasites genus, we studied effects of several compounds from Petas...See full text at original site
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引用元：
https://doi.org/10.1016/j.jep.2015.12.010

データ提供：米国国立医学図書館（NLM）

Petatewalide B: A New Hope for Allergies?

This research takes us on a journey into the world of traditional medicine, exploring the anti-allergic properties of a novel compound called petatewalide B, isolated from the giant butterbur plant, *Petasites japonicus*. The researchers tested the compound's effects in various in vitro and in vivo models, including mast cells, macrophages, and an ovalbumin-induced asthma model. This research is intriguing as it delves into the potential of natural compounds for alleviating allergy symptoms.

Petatewalide B: A Potential Anti-Allergic Agent

The study demonstrated that petatewalide B effectively inhibited antigen-induced degranulation of mast cells, reduced inflammation in the ovalbumin-induced asthma model, and inhibited nitric oxide production in macrophages. These findings suggest that petatewalide B may hold potential as a new treatment for allergies.

Natural Remedies: Exploring New Avenues

This study highlights the potential of natural compounds for treating allergic conditions. While further research is needed to confirm the efficacy and safety of petatewalide B in humans, this research offers a promising avenue for exploring new therapies for allergies.

Dr.Camel's Conclusion

This study, like a camel seeking out a rare desert flower, explores the potential of a natural compound for combating allergies. Petatewalide B shows promise as a potential anti-allergic agent, opening doors for new avenues in allergy treatment.

Date :
  1. Date Completed 2016-10-14
  2. Date Revised 2016-12-30
Further Info :

Pubmed ID

26674157

DOI: Digital Object Identifier

10.1016/j.jep.2015.12.010

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Languages

English

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