Paper Details

  1. Home
  2. Paper Details

Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: formulation, optimization, evaluation and permeation studies.

Author: DhamechaDinesh, JalalpureSunil, ShahiSadhana, ShelkeSantosh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Zolmitriptan, a migraine medication, has limited oral bioavailability and can lead to frequent dosing and side effects. This study developed thermoreversible intranasal gels loaded with zolmitriptan-loaded nanoethosomes to improve drug delivery and reduce these limitations. The optimized formulation showed improved drug entrapment, release, and permeation, suggesting its potential as a more effective migraine treatment.
Paper Details　
Original Abstract of the Article :
Zolmitriptan is the drug of choice for migraine, but low oral bioavailability (<50%) and recurrence of migraine lead to frequent dosing and increase in associated side effects. Increase in the residence time of drug at the site of drug absorption along with direct nose to brain targeting of zolmitri...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/08982104.2015.1132232

データ提供：米国国立医学図書館（NLM）

Zolmitriptan Nanoethosomes: A Novel Approach to Migraine Treatment

This research investigates the potential of a novel drug delivery system for zolmitriptan, a medication used to treat migraine headaches. The study focuses on developing a thermoreversible intranasal gel containing zolmitriptan-loaded nanoethosomes. This formulation aims to enhance the drug's bioavailability and target it directly to the brain, potentially improving treatment outcomes and reducing side effects.

Delivering Relief: Navigating the Labyrinth of Migraine Treatment

This research highlights the challenges associated with migraine treatment, particularly the issue of low oral bioavailability and the need for frequent dosing. Just as a camel navigates a labyrinthine desert, researchers are seeking innovative solutions to optimize migraine treatment. The study explores the promise of nanoethosomes and intranasal delivery as potential breakthroughs in migraine management.

A Journey Towards Headache Relief: Exploring New Options

This research offers hope for those suffering from migraines. The study's findings suggest that a novel drug delivery system using nanoethosomes and intranasal administration could offer a more effective and convenient way to manage this debilitating condition. The research encourages individuals to discuss treatment options with their healthcare providers and explore new approaches to migraine management.

Dr. Camel's Conclusion

This research explores the potential of a thermoreversible intranasal gel containing zolmitriptan-loaded nanoethosomes as a novel approach to migraine treatment. The study highlights the need for innovative drug delivery systems to improve treatment outcomes and reduce side effects, offering a glimpse into the future of migraine management.
Date :
  1. Date Completed 2017-04-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26758957

DOI: Digital Object Identifier

10.3109/08982104.2015.1132232

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.