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Relation of serum molindone levels to serum prolactin levels and antipsychotic response.

Author: BlackardW G, LandaB S, NarasimhachariN, PandurangiA K

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Molindone showed therapeutic benefit in psychotic patients, with significant relations between serum levels and prolactin levels and treatment response.
Paper Details　
Original Abstract of the Article :
The antipsychotic drug molindone is considered to be atypical in its mode of action and to have mild side effects. Currently no data are available on the range of serum levels of this drug during treatment. By means of a high performance liquid chromatographic technique, serum molindone levels were ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2676994

データ提供：米国国立医学図書館（NLM）

Molindone: Unveiling the Therapeutic Landscape

This study delves into the relationship between serum molindone levels, serum prolactin levels, and antipsychotic response. The researchers aimed to establish a therapeutic range for molindone, an atypical antipsychotic drug known for its milder side effects. By employing a high-performance liquid chromatographic technique, they measured serum molindone levels in a group of patients receiving varying doses of the drug.

Molindone: A Prolactin-Probing Antipsychotic

The study found that molindone levels as high as 350 ng/mL were achieved without any apparent toxic effects. Furthermore, they established a significant correlation between the serum level of the drug and both serum prolactin level and treatment response. This suggests that molindone may have a therapeutic range, and serum levels of molindone and prolactin could be valuable tools to assess resistance to molindone treatment.

Molindone: A Journey Through the Mind

This research provides crucial insights into the therapeutic use of molindone, highlighting the importance of monitoring serum levels to optimize treatment and identify resistance. Understanding the relationship between molindone levels and prolactin levels can help clinicians tailor treatment strategies for individual patients.

Dr. Camel's Conclusion

This research provides valuable insights into the therapeutic use of molindone, highlighting the relationship between serum levels, prolactin levels, and antipsychotic response. Monitoring these levels can aid in optimizing treatment and identifying resistance, leading to more effective management of this atypical antipsychotic drug.
Date :
  1. Date Completed 1989-11-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2676994

DOI: Digital Object Identifier

2676994

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Article Analysis
・Side Effects of molindone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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