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A Phase 2 Randomized Controlled Trial of Personalized Peptide Vaccine Immunotherapy with Low-dose Dexamethasone Versus Dexamethasone Alone in Chemotherapy-naive Castration-resistant Prostate Cancer.

Author: EgawaShin, FujimotoHiroyuki, ItohKyogo, KimuraTakahiro, MinamiTakafumi, NozawaMasahiro, UemuraHirotsugu, YamadaAkira, YoshimuraKazuhiro

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Personalized peptide vaccine (PPV) immunotherapy was well tolerated and associated with longer PSA progression-free survival and overall survival in men with chemotherapy-naive castration-resistant prostate cancer (CRPC).
Paper Details　
Original Abstract of the Article :
BACKGROUND: It is well known that the prognosis of castration-resistant prostate cancer (CRPC) is poor, and several immunotherapeutic strategies have been applied to the clinical trials. Research on immunotherapy has been of special interest for the treatment of CRPC for years. OBJECTIVE: To evalua...See full text at original site
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引用元：
https://doi.org/10.1016/j.eururo.2015.12.050

データ提供：米国国立医学図書館（NLM）

Personalized Peptide Vaccine Immunotherapy for Prostate Cancer: A New Oasis in the Desert of Treatment Options

This study investigates the effectiveness of [personalized peptide vaccine (PPV) immunotherapy] in treating [chemotherapy-naive castration-resistant prostate cancer (CRPC)]. The authors conducted a [phase 2 randomized controlled trial] to compare the outcomes of [PPV immunotherapy with low-dose dexamethasone] versus [dexamethasone alone] in [37 patients]. They analyzed [PSA, progression-free survival (PFS), time to initiation of chemotherapy, and overall survival (OS)].

Promising Results for Prostate Cancer Treatment

The study found that [PPV immunotherapy] was [well tolerated] and associated with [longer PSA PFS and OS] in men with [chemotherapy-naive CRPC]. The authors emphasize the need for a [larger phase 3 study] to confirm their findings.

Navigating the Desert of Prostate Cancer Treatment: Personalized Hope

This research offers a glimmer of hope for individuals battling [CRPC]. It highlights the potential of [personalized immunotherapy] in tailoring treatment approaches to individual needs. Just as a camel adapts to the harsh desert environment, it's essential to find the right treatment approach that caters to individual needs and preferences.

Dr.Camel's Conclusion

This study represents a significant step forward in the development of [immunotherapy] for [prostate cancer]. It underscores the potential of [personalized medicine] in transforming treatment approaches. As a desert wanderer, I'm always inspired by the relentless pursuit of innovative therapies that can improve the lives of those facing challenging [health conditions].

Date :
  1. Date Completed 2017-12-21
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

26782346

DOI: Digital Object Identifier

10.1016/j.eururo.2015.12.050

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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