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[Evaluation of the efficacy and tolerability of a fixed dose combination of captopril (CPT) 50 mg and hydrochlorothiazide (HCTZ) 15 mg in the elderly].

Author: AntonicelliR, BossiniA, BottaG F, PaciaroniE, RaffaelliS, ZingarettiP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Captopril 50 mg + hydrochlorothiazide 15 mg/die was more effective in lowering diastolic blood pressure than hydrochlorothiazide 25 mg/die in elderly patients with hypertension.
Paper Details　
Original Abstract of the Article :
In this double blind study we have evaluated the efficacy and tolerability of the association Captopril 50 mg + hydrochlorothiazide 15 mg/die vs hydrochlorothiazide 25 mg/die in aged patients with hypertension. Both drugs showed a good antihypertensive efficacy, and a better efficacy on diastolic bl...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2678309

データ提供：米国国立医学図書館（NLM）

Captopril and Hydrochlorothiazide: A Powerful Combination for Hypertension

The quest to manage hypertension, a silent but dangerous condition, is a journey through the desert of cardiovascular research. This study evaluates the efficacy and tolerability of a fixed-dose combination of captopril and hydrochlorothiazide in the treatment of hypertension in elderly patients. The researchers conducted a double-blind study comparing the effects of the combination therapy with hydrochlorothiazide alone.

Captopril and Hydrochlorothiazide: A Synergistic Approach to Hypertension

The study demonstrates that both the combination therapy and hydrochlorothiazide alone showed good antihypertensive efficacy. However, the combination therapy displayed a more pronounced effect on diastolic blood pressure, indicating a synergistic benefit.

Implications for Hypertension Treatment

The findings suggest that the combination of captopril and hydrochlorothiazide may offer a more effective approach to controlling hypertension in elderly patients. However, further research is needed to assess the long-term safety and efficacy of this therapy.

Dr.Camel's Conclusion

The desert of hypertension research is vast and complex, with many challenges to overcome. This study provides valuable insights into the potential of captopril and hydrochlorothiazide combination therapy to improve blood pressure control. As we continue to explore new frontiers in hypertension management, we aim to find solutions that promote heart health and improve the lives of those affected by this condition.

Date :
  1. Date Completed 1989-11-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2678309

DOI: Digital Object Identifier

2678309

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Article Analysis
・Effects of captopril and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

Italian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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