Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study.

Author: , AktasOrhan, AyzenbergIlya, BertheleAchim, HellwigKerstin, HoepnerRobert, JariusSven, KleiterIngo, KrumbholzMarkus, KümpfelTania, ObermannMark, PacheFlorence, PaulFriedemann, RingelsteinMarius, SchwabMatthias, SchöllhammerJoanna, TrebstCorinna, ZeltnerLena

Paper Details 
Original Abstract of the Article :
Glatiramer acetate (GA) is an approved therapy for relapsing-remitting multiple sclerosis, but its efficacy for the prevention of attacks in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. We did a multicenter retrospective analysis of GA-treated patients with NMOSD, identified throu...See full text at original site
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引用元:
https://doi.org/10.1007/s00415-015-7991-1

データ提供:米国国立医学図書館(NLM)

Glatiramer Acetate for Neuromyelitis Optica Spectrum Disorder: A Retrospective Study

Neuromyelitis optica spectrum disorder (NMOSD), a debilitating autoimmune disease that affects the central nervous system, requires effective treatment options. This study investigates the use of glatiramer acetate (GA), a medication approved for treating multiple sclerosis, for preventing attacks in NMOSD. The researchers analyzed data from a national registry of NMOSD patients treated with GA, evaluating its efficacy in reducing relapse rates. Their findings raise questions about the effectiveness of GA for NMOSD and highlight the need for further research.

A Desert of Uncertainties in NMOSD Treatment

The study found that GA did not significantly reduce the annualized relapse rate in NMOSD patients, particularly in those who were positive for aquaporin-4 antibodies. This finding is like encountering a deceptive mirage in the desert of NMOSD research, suggesting that GA might not be as effective as initially hoped for this condition. The study also observed an increase in the median expanded disability status scale (EDSS) score, indicating that GA might not be effective in preventing disease progression. This suggests that other treatment options might be necessary for managing NMOSD.

A Search for New Oases in NMOSD

This study provides valuable insights into the use of GA for NMOSD. The findings highlight the need for further research to understand the role of GA in this condition. This study reminds us that the desert of NMOSD research is complex and ever-changing, and that we must continue to seek out new and effective treatments for patients with this challenging disease.

Dr. Camel's Conclusion

This study underscores the need for further research to explore more effective treatments for NMOSD. The findings highlight the importance of individualizing treatment plans and carefully monitoring patients for response and potential side effects. In the vast and often unforgiving desert of neurological disease, we must continuously seek out new and effective treatment options to improve the lives of our patients.
Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26810718

DOI: Digital Object Identifier

10.1007/s00415-015-7991-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

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