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Bioequivalent doses of budesonide and prednisone in moderate and severe asthma.

Author: BaskervilleJ, JenningsB, JohanssonS A, LefcoeN M, ToogoodJ H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inhaled budesonide was equally effective as oral prednisone in treating asthma, but at lower doses, resulting in less systemic glucocorticoid activity.
Paper Details　
Original Abstract of the Article :
We determined the relative antiasthmatic and systemic glucocorticoid potencies of inhaled budesonide (BUD) versus morning-dose oral prednisone (PRED) in 34 adult patients with asthma over a dose range extending from conventional to high and potentially toxic levels, 3.2 mg of BUD or 40 mg of PRED pe...See full text at original site
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引用元：
https://doi.org/10.1016/0091-6749(89)90297-2

データ提供：米国国立医学図書館（NLM）

Asthma Treatment: Finding the Right Balance

This research compares the efficacy and systemic effects of inhaled budesonide (BUD) and oral prednisone (PRED) in patients with moderate to severe asthma. The study found that both medications were equally effective in controlling asthma symptoms, but BUD exhibited a lower level of systemic glucocorticoid activity at equivalent antiasthmatic doses. This suggests that BUD may be a safer option for patients with severe asthma, as it can effectively control symptoms while minimizing the risk of steroid-induced complications like osteoporosis. The study highlights the importance of individualizing treatment approaches to optimize asthma management and minimize potential side effects.

Navigating the Asthma Treatment Desert: Finding the Right Path

This research highlights the importance of finding the right treatment path for individuals with asthma, considering both efficacy and potential side effects. It's like navigating a vast desert, where each individual's needs and sensitivities require a tailored approach. The study demonstrates that BUD can offer a safer and more effective alternative for patients with severe asthma, allowing them to breathe freely while minimizing the risk of long-term complications.

Finding the Oasis: Optimizing Asthma Management

This study emphasizes the importance of optimizing asthma management through individualized treatment approaches. It's like seeking an oasis in the desert, where a personalized plan can provide relief and long-term well-being. By carefully weighing the benefits and risks of different medications, healthcare providers can guide patients toward the most appropriate treatment options, maximizing their quality of life.

Dr.Camel's Conclusion

This research highlights the importance of finding the right balance in asthma treatment, balancing efficacy with potential side effects. It's like finding the perfect spot in the desert, where the shade of a tree offers relief from the sun, while the clear, cool water quenches thirst. By choosing the appropriate medication and carefully monitoring its effects, individuals with asthma can navigate their journey with confidence and enjoy a better quality of life.

Date :
  1. Date Completed 1989-12-20
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

2681331

DOI: Digital Object Identifier

10.1016/0091-6749(89)90297-2

Related Literature

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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