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Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Author: LaverrièreAlexandra, MacDonaldLaura C I, RollasonVictoria, TramèrMartin R, Vogt-FerrierNicole B, WalshTanya

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Bisphosphonates are medications used to prevent and treat osteoporosis and bone problems related to cancer. While generally safe, they can cause a rare but serious side effect called osteonecrosis of the jaw (BRONJ), where the jawbone dies. There's no single best treatment for BRONJ, and approaches include oral rinses, antibiotics, surgery, and other therapies.
Paper Details　
Original Abstract of the Article :
Bisphosphonate drugs can be used to prevent and treat osteoporosis and to reduce symptoms and complications of metastatic bone disease; however, they are associated with a rare but serious adverse event: osteonecrosis of the maxillary and mandibular bones. This condition is called bisphosphonate-rel...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173706/

データ提供：米国国立医学図書館（NLM）

Bisphosphonate-Related Osteonecrosis of the Jaw: A Complex Condition

The world of bone health is vast and complex, much like a desert landscape with its diverse terrain and hidden dangers. This study delves into the realm of bisphosphonate-related osteonecrosis of the jaw (BRONJ), a serious adverse event associated with bisphosphonate medications. The researchers discuss the various interventions available for treating BRONJ, aiming to provide a comprehensive overview of the current treatment landscape.

Navigating the Challenges of BRONJ Treatment

The study highlights the challenges of treating BRONJ, emphasizing the lack of a definitive gold standard treatment. It's like navigating a treacherous desert, where the path to recovery is uncertain and requires careful consideration. The researchers discuss three broad categories of interventions: conservative approaches, surgical interventions, and adjuvant non-surgical strategies, highlighting the complex nature of BRONJ management.

Seeking Effective Solutions for BRONJ

The study underscores the need for further research and development of effective treatments for BRONJ. It's like seeking a reliable source of water in a parched desert, searching for a solution to alleviate the suffering of patients with this debilitating condition. The researchers emphasize the importance of exploring new and innovative approaches to address the challenges of BRONJ treatment.

Dr.Camel's Conclusion

This study provides a valuable overview of the current approaches to managing BRONJ, a complex condition with a significant impact on patients' lives. It's a reminder that the quest for effective treatments for bone disorders is a continuous journey, much like traversing a vast desert landscape. Further research and clinical trials are needed to develop new and innovative solutions for BRONJ, ensuring optimal care for affected individuals.

Date :
  1. Date Completed 2016-06-20
  2. Date Revised 2023-11-13
Further Info :

Pubmed ID

26919630

DOI: Digital Object Identifier

PMC7173706

SNS
PICO Info
in preparation
Languages

English

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