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Low-grade and anaplastic oligodendroglioma.

Author: BrombergJacolien E C, BucknerJan, Van Den BentMartin J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the treatment of anaplastic oligodendrogliomas, a type of brain tumor. The review highlights the role of chemotherapy, particularly PCV (procarbazine, lomustine, vincristine), as a standard of care for these tumors, especially in those with 1p/19q co-deletion.
Paper Details　
Original Abstract of the Article :
Anaplastic oligodendrogliomas have long attracted interest because of their sensitivity to chemotherapy, in particular in the subset of 1p/19q co-deleted tumors. Recent molecular studies have shown that all 1p/19q co-deleted tumors have IDH mutations and most of them also have TERT mutations. Becaus...See full text at original site
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引用元：
https://doi.org/10.1016/B978-0-12-802997-8.00022-0

データ提供：米国国立医学図書館（NLM）

Oligodendroglioma: Understanding Its Molecular Landscape

Imagine a hidden oasis in a vast desert, its existence unknown until a traveler stumbles upon it. This is similar to the discovery of the molecular characteristics of oligodendroglioma, a type of brain tumor. This article discusses the current understanding of oligodendroglioma, its genetic features, and the standard of care for its treatment.

The Molecular Landscape of Oligodendroglioma

The study highlights the importance of genetic testing in diagnosing and treating oligodendroglioma. Researchers have identified specific genetic alterations, like the co-deletion of chromosomes 1p and 19q, that are associated with better response to chemotherapy. This molecular information has revolutionized the way we understand and treat this type of brain tumor, offering targeted therapies for specific genetic subtypes.

Personalized Approaches to Brain Tumor Treatment

This research underscores the importance of precision medicine in treating brain tumors. By identifying the molecular characteristics of the tumor, doctors can tailor treatment strategies to maximize effectiveness and minimize side effects. This study is like a map leading us through the complex landscape of brain tumor genetics, guiding us towards more effective treatments and a better understanding of these challenging diseases.

Dr.Camel's Conclusion

The desert of brain tumor research is vast and complex, but with each new discovery, we gain a deeper understanding of these challenging diseases. This research sheds light on the molecular landscape of oligodendroglioma, paving the way for more effective and targeted treatments. It’s like finding a hidden spring in the desert, providing a source of hope and new possibilities for patients battling brain tumors.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26948366

DOI: Digital Object Identifier

10.1016/B978-0-12-802997-8.00022-0

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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