Paper Details

  1. Home
  2. Paper Details

Effect of retinoic acid on aquaporin 3 expression in keratinocytes.

Author: JiangP, JinX, LiaoW, XingF, XuW

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Retinoic acid medications, such as isotretinoin, acitretin, and adapalene, can cause skin and mucosal dryness. This study found that retinoic acid can increase AQP3 expression in keratinocyte cells, suggesting a potential mechanism for these side effects.
Paper Details　
Original Abstract of the Article :
To explore the possible mechanism of the third-generation retinoic acid drugs (isotretinoin, acitretin, adapalene) in inducing skin and mucosa dryness and rhagades; specifically, mechanism by which these drugs influence keratinocyte cell culture models in vitro (HaCaT) and aquaporin channel (AQP3) p...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.4238/gmr.15016951

データ提供：米国国立医学図書館（NLM）

Retinoic Acid and Aquaporin 3: Unraveling the Mechanism of Skin Dryness

Retinoids, a class of drugs derived from vitamin A, are commonly used to treat acne and other skin conditions. However, they can also cause unwanted side effects such as skin and mucosa dryness. This study delves into the mechanism behind this phenomenon, exploring the interaction between retinoic acid and aquaporin 3 (AQP3), a protein involved in water transport in the skin.

Retinoic Acid's Role in Skin Hydration

The researchers investigated the effects of different retinoic acid drugs on AQP3 expression in keratinocytes, cells that form the outer layer of the skin. They found that retinoic acid can increase AQP3 expression, which could potentially lead to increased water loss from the skin, resulting in dryness. Imagine a desert, its precious water sources drying up due to increased evaporation, much like the skin can lose moisture when AQP3 expression is increased.

Managing Skin Dryness: Balancing the Benefits and Risks

This study sheds light on the potential mechanisms behind skin dryness caused by retinoid drugs. By understanding the interaction between retinoic acid and AQP3, researchers can potentially develop strategies to mitigate these side effects while preserving the beneficial effects of these drugs. Much like a traveler navigating a desert, we must learn to balance the benefits and risks of retinoid therapy to optimize skin health.

Dr. Camel's Conclusion

This research provides valuable insights into the mechanism behind skin dryness caused by retinoid drugs. The researchers' findings suggest that retinoic acid may influence AQP3 expression, which could play a role in water loss from the skin. This understanding is crucial for developing strategies to minimize these side effects and ensure optimal skin health.
Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2016-12-30
Further Info :

Pubmed ID

26985947

DOI: Digital Object Identifier

10.4238/gmr.15016951

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.