Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study.

Author: AggarwalNiti, AngiolilloDominick J, AntounPatrick, BassTheodore A, Cox-AlomarPedro, DurairajAshwin, FranchiFrancesco, GuzmanLuis A, HuJenny, KuretiMegha, ParkYongwhi, RolliniFabiana, SeawellMichael, SuryadevaraSiva, ZenniMartin M

Paper Details 
Original Abstract of the Article :
Platelet inhibitory effects induced by oral P2Y12 receptor antagonists are delayed in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), which may be attributed to impaired absorption affecting drug pharmacokinetics (PK) and...See full text at original site
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引用元:
https://doi.org/10.1016/j.jacc.2016.02.045

データ提供:米国国立医学図書館(NLM)

Crushed Prasugrel Tablets for STEMI Patients: A Potential for Improved Outcomes

In the fast-paced world of cardiology, every minute counts when treating patients with ST-segment elevation myocardial infarction (STEMI), a serious heart attack.

This study investigates the potential benefits of crushing prasugrel tablets in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Prasugrel is a medication that inhibits platelet aggregation, reducing the risk of blood clots. However, the drug's effects are delayed in STEMI patients, potentially due to impaired absorption. Crushing tablets has been proposed as a way to improve drug pharmacokinetics and pharmacodynamics, leading to more favorable outcomes.

This study explores the potential of crushing prasugrel tablets for STEMI patients undergoing PPCI, seeking to determine if this approach can improve drug absorption and efficacy.

Improving Drug Delivery: A New Approach to STEMI Treatment

This study suggests that crushing prasugrel tablets may offer a promising way to improve drug absorption and efficacy in STEMI patients undergoing PPCI. This could lead to more effective treatment and potentially better outcomes for these patients.

Navigating the Critical Path of STEMI Treatment: A Race Against Time

This research highlights the importance of finding innovative ways to optimize drug delivery and improve treatment outcomes for STEMI patients. Like a camel racing against time to reach a vital oasis, we must be prepared to explore new approaches and strategies to effectively address this critical medical condition.

Dr.Camel's Conclusion

This research underscores the importance of optimizing drug delivery and treatment strategies for STEMI patients. Like a camel navigating the treacherous sands of a heart attack, we must be prepared to adapt and innovate to provide the best possible care for those in need.

Date :
  1. Date Completed 2017-06-06
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

27012781

DOI: Digital Object Identifier

10.1016/j.jacc.2016.02.045

Related Literature

SNS
PICO Info
in preparation
Languages

English

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