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Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial.

Author: BaldwinDavid, BarnesThomas R E, CostelloeCéire, CraigTom K J, CrawfordMike, GeddesJohn, IsmailShajahan, KeownPatrick, KillaspyHelen, KissNoemi, KumarManoj, LeesonVerity C, LewisGlyn, LewisShôn, OsbornDavid, PathakRudresh, PatonCarol, SimonJudit, TaylorSimon

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Negative symptoms of schizophrenia, such as lack of motivation and social engagement, are a major obstacle to recovery. While no specific medications are approved for treating these symptoms, some evidence suggests a combination of antipsychotics and antidepressants might be helpful. However, more research is needed to confirm this and develop effective treatments.
Paper Details　
Original Abstract of the Article :
Negative symptoms of schizophrenia represent deficiencies in emotional responsiveness, motivation, socialisation, speech and movement. When persistent, they are held to account for much of the poor functional outcomes associated with schizophrenia. There are currently no approved pharmacological tre...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860560/

データ提供：米国国立医学図書館（NLM）

Treating Negative Symptoms of Schizophrenia

This research focuses on the challenging area of treating negative symptoms of schizophrenia, a condition that can be likened to a desert oasis that is slowly drying up, leaving behind a sense of emptiness and disconnection. The researchers conducted a double-blind, placebo-controlled, randomized clinical trial called ACTIONS (Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia). They investigated whether a combination of antipsychotic and antidepressant medication could be effective in treating negative symptoms. Although previous evidence suggests that this combination might be helpful, the evidence was insufficient to draw firm conclusions. It's like trying to navigate a sandstorm with a limited map, where you need more information to find your way. This research is like adding more detail to that map, helping us understand this complex condition better.

The Potential for Combining Medications

The research suggests that a combination of antipsychotic and antidepressant medication might be effective in treating negative symptoms of schizophrenia. This is significant because there are currently no approved pharmacological treatments specifically for these symptoms.

Managing Schizophrenia Effectively

This research emphasizes the need for further investigation into effective treatments for negative symptoms of schizophrenia. It's important to find ways to help individuals with this condition manage their symptoms and live fulfilling lives. Just as a camel needs a constant supply of water in the desert, individuals with schizophrenia need ongoing support and effective treatments.

Dr. Camel's Conclusion

This research highlights the need for innovative approaches to treat negative symptoms of schizophrenia. It's like searching for a hidden oasis in the vast desert, seeking solutions that can bring relief and improve quality of life. The journey to better understand and treat this complex condition continues, and this research is a valuable step in the right direction.

Date :
  1. Date Completed 2017-01-09
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

27094189

DOI: Digital Object Identifier

PMC4860560

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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