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Effects on agitation with rivastigmine patch monotherapy and combination therapy with memantine in mild to moderate Alzheimer's disease: a multicenter 24-week prospective randomized open-label study (the Korean EXelon Patch and combination with mEmantine Comparative Trial study).

Author: ChoiSeong H, HanHyun J, KimEun-Joo, LeeJae-Hong, NaDuk L, NaHae R, ParkKyung-Won, ShimYoung S, YoonSoo J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Memantine is an effective treatment for behavioral symptoms of dementia, especially agitation in patients with moderate to severe Alzheimer's disease (AD). However, the effectiveness of combining memantine and rivastigmine patch therapy for mild to moderate AD patients remains unclear.
Paper Details　
Original Abstract of the Article :
Memantine is known to be effective in the treatment of the behavioral symptoms of dementia, especially agitation in moderate to severe Alzheimer's disease (AD). However, memantine and rivastigmine patch combination therapy has not been well studied in determining treatment effectiveness with mild to...See full text at original site
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引用元：
https://doi.org/10.1111/ggi.12754

データ提供：米国国立医学図書館（NLM）

Memantine and Rivastigmine: A Collaborative Journey to Treat Agitation in Alzheimer's Disease

This study explores the effectiveness of rivastigmine patch monotherapy and combination therapy with memantine in treating agitation in patients with mild to moderate Alzheimer’s disease (AD). The researchers conducted a 24-week prospective randomized open-label study to compare the effects of these treatments on agitation symptoms in individuals with AD. The study aims to evaluate the efficacy and safety of these treatments for managing agitation in patients with AD.

A Oasis of Calm: Addressing Agitation in Alzheimer's Disease

The study investigates the potential benefits of rivastigmine patch monotherapy and combination therapy with memantine in managing agitation in patients with mild to moderate AD. The researchers aim to identify effective treatment approaches for this challenging symptom, which can significantly impact quality of life for individuals with AD and their caregivers.

A Journey Through the Desert of Dementia: Seeking Effective Treatment Options

This research underscores the need for effective treatments for agitation in patients with AD, particularly those in the mild to moderate stages. The study’s findings may provide valuable insights into the potential benefits of rivastigmine patch therapy, both alone and in combination with memantine, in managing agitation and improving quality of life for individuals with AD.

Dr. Camel's Conclusion

This study offers a promising glimpse into the potential of rivastigmine patch therapy and combination therapy with memantine in treating agitation in patients with Alzheimer’s disease. It’s like finding a hidden oasis of tranquility in the desert of dementia, offering a path toward reducing agitation and improving quality of life for individuals with AD and their caregivers.

Date :
  1. Date Completed 2018-01-08
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

27111084

DOI: Digital Object Identifier

10.1111/ggi.12754

Related Literature

Article Analysis
・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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