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Absolute bioavailability and noncompartmental analysis of intravenous and intramuscular Cefotan (cefotetan) in normal volunteers.

Author: CohenA, ThyrumP, ZimmermanJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cefotetan, an antibiotic, was rapidly and almost completely absorbed after intramuscular injection. It was excreted primarily in the urine.
Paper Details　
Original Abstract of the Article :
Cefotetan (1 g) was administered to 12 normal volunteers as a 30 minute intravenous infusion and as an intramuscular injection. The pharmacokinetic parameters were estimated using noncompartmental analysis. The mean +/- SD maximum plasma concentration, terminal half-life, and systemic clearance afte...See full text at original site
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引用元：
https://doi.org/10.1002/j.1552-4604.1989.tb03304.x

データ提供：米国国立医学図書館（NLM）

Cefotetan: A Look at Its Pharmacokinetic Profile

The study investigates the pharmacokinetic properties of Cefotetan, an antibiotic commonly used to treat bacterial infections. The researchers analyze the drug's absorption, distribution, metabolism, and excretion after both intravenous and intramuscular administration. They aim to better understand how Cefotetan behaves in the body.

Intravenous Versus Intramuscular Administration

The study found that Cefotetan is rapidly and almost completely absorbed after intramuscular injection. The pharmacokinetic parameters were similar after intravenous and intramuscular administration, suggesting that both routes are effective in achieving therapeutic levels of the drug.

Cefotetan: A Versatile Antibiotic

The study demonstrates that Cefotetan is a versatile antibiotic that can be administered intravenously or intramuscularly, providing a range of options for treating infections. Understanding the pharmacokinetic profile of this drug is crucial for optimizing treatment and ensuring effective antimicrobial therapy.

Dr. Camel's Conclusion

This study provides a detailed pharmacokinetic profile of Cefotetan, guiding us through the intricate pathways of drug absorption, distribution, and elimination. It reminds us that even in the vast desert of medicine, there are precise mechanisms at work that ensure the effectiveness of treatment.

Date :
  1. Date Completed 1989-06-15
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2715372

DOI: Digital Object Identifier

10.1002/j.1552-4604.1989.tb03304.x

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・Effects of cefotetan injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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