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Cytostatic activity of commonly used tricyclic antidepressants.

Author: SauterC

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tricyclic antidepressants (TA) have cytostatic properties on human renal cancer cells in vitro. Their potential antineoplastic influence in cancer chemotherapy needs further investigation.
Paper Details　
Original Abstract of the Article :
Tricyclic antidepressants (TA) often used in the supportive care of cancer patients exhibit cytostatic properties on human renal cancer cells in vitro. Complete growth inhibition was observed with imipramine and clomipramine at concentrations similar to that of nitrogen mustard. Clinical side effect...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.1159/000226705

データ提供：米国国立医学図書館（NLM）

Cytostatic activity of commonly used tricyclic antidepressants

This research explores the potential anti-cancer effects of tricyclic antidepressants (TCAs), a class of drugs commonly used to treat depression. The study investigates the ability of TCAs to inhibit the growth of human renal cancer cells in laboratory settings.

Unveiling the Hidden Potential of Tricyclic Antidepressants

This research suggests that TCAs, widely known for their role in treating depression, may possess anti-cancer properties. The study demonstrates that TCAs can effectively inhibit the growth of renal cancer cells, opening up new avenues for exploring their potential use in cancer therapy.

A New Perspective on Tricyclic Antidepressant Use

This research challenges our understanding of the therapeutic applications of TCAs. It suggests that these medications, already used to treat mental health conditions, may hold promise in the treatment of cancer.

Dr. Camel's Conclusion

This research is a reminder that even familiar substances can have hidden potential. Like a desert wind carrying seeds to unexpected destinations, TCAs may hold the key to new treatments for cancer. This study encourages us to explore the potential of existing medications in new ways to address challenging health problems.

Date :
  1. Date Completed 1989-06-21
  2. Date Revised 2018-02-16
Further Info :

Pubmed ID

2717124

DOI: Digital Object Identifier

10.1159/000226705

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