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Rizatriptan overuse promotes hyperalgesia induced by dural inflammatory stimulation in rats by modulation of the serotonin system.

Author: HanXun, LiRuisheng, LiuYufei, RanYe, SuMin, TanQingche, YuShengyuan, ZhangXu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the role of serotonin (5-HT) and the 5-HT2A receptor (5-HT2AR) in medication-overuse headache (MOH) using a novel animal model. Overuse of rizatriptan (RIZ) and dural inflammatory soup (IS) stimulation induced nociception-related behaviors, increased Fos expression, and decreased periorbital withdrawal threshold. Chronic RIZ exposure and recurring nociception decreased 5-HT expression, while IS-RIZ treatment led to decreased 5-HT expression and upregulation of 5-HT2AR. These findings suggest that medication overuse and frequent headache attacks can promote the neural plasticity associated with MOH, potentially involving 5-HT and 5-HT2AR.
Paper Details　
Original Abstract of the Article :
Clinical and preclinical studies have implicated serotonin (5-HT) and the 5-HT2A receptor (5-HT2AR) in the pathogenesis of medication-overuse headache (MOH). However, with no appropriate animal model to study this phenomenon it is difficult to differentiate the effects of chronic exposure to analges...See full text at original site
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引用元：
https://doi.org/10.1111/ejn.13296

データ提供：米国国立医学図書館（NLM）

Rizatriptan Overuse and Headache: A Cautionary Tale in the Desert of Pain

Medication overuse headache (MOH), a chronic condition that arises from excessive reliance on pain relievers, is like a desert mirage, offering temporary relief but ultimately leading to more pain. This study, like a wise explorer navigating the treacherous terrain of pain, examines the role of rizatriptan, a triptan medication used to treat migraines, in the development of MOH. The researchers discovered that overuse of rizatriptan can actually promote hyperalgesia, a heightened sensitivity to pain, in rats exposed to dural inflammatory stimulation. This finding highlights the potential downsides of frequent medication use and underscores the importance of responsible pain management.

Navigating the Desert of Pain: Finding Sustainable Solutions

This study, like a careful analysis of the desert's ecosystem, reveals the complex interplay between medication overuse and pain perception. The researchers found that overuse of rizatriptan can lead to changes in the serotonin system, a neurotransmitter system involved in pain modulation. This disruption, much like a disruption in the delicate balance of a desert ecosystem, can contribute to increased pain sensitivity.

A Path to Wellness: Avoiding the Pitfalls of Medication Overuse

This study serves as a cautionary tale in the desert of pain, reminding us of the potential pitfalls of excessive medication use. By understanding the risks associated with medication overuse, we can better navigate the terrain of pain management, making informed choices that promote long-term wellness.

Dr. Camel's Conclusion

This study highlights the importance of responsible pain management, reminding us that even well-intentioned solutions can have unintended consequences. By understanding the complexities of pain perception and the potential risks of medication overuse, we can work towards sustainable pain management strategies that promote long-term health and well-being.
Date :
  1. Date Completed 2018-02-01
  2. Date Revised 2018-04-26
Further Info :

Pubmed ID

27288111

DOI: Digital Object Identifier

10.1111/ejn.13296

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・Effects of rizatriptan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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