Mechanism of Action of Novel Glibenclamide Derivatives on Potassium and Calcium Channels for Insulin Secretion.

Author: CastroAllisson Jhonatan Gomes, FredericoMarisa Jadna Silva, MascarelloAlessandra, MendesCamila Pires, MenegazDanusa, MuratCahue De Bernardis, NunesRicardo Jose, SilvaFatima Regina Mena Barreto

Paper Details 
Original Abstract of the Article :
Glibenclamide is widely used and remains a cornerstone and an effective antihyperglycemic drug. After the casual discovery of its hypoglycemic potential, this compound was introduced for diabetes treatment. However, the long-term side effects reveal that glibenclamide should be replaced by new molec...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/27316908

データ提供:米国国立医学図書館(NLM)

Glibenclamide: A New Generation of Diabetes Treatments?

Diabetes, a persistent challenge for millions worldwide, is like a desert storm, threatening to disrupt the balance of life. This review delves into the fascinating world of glibenclamide, a mainstay medication for diabetes, and its derivatives. The authors, like explorers mapping a new terrain, examine the mechanisms by which glibenclamide and its newer variations influence potassium and calcium channels in beta cells, the key players in insulin secretion. The goal? To find new and more effective treatments for diabetes, with fewer side effects.

Glibenclamide Derivatives: A Promising Path in the Desert

The review highlights the potential of glibenclamide derivatives to offer more targeted and less disruptive approaches to regulating blood sugar. These derivatives, like different oases with unique qualities, hold promise in terms of their effectiveness and safety, offering a more sustainable path to managing diabetes.

Hope for a Brighter Future in Diabetes Management

The research suggests that glibenclamide derivatives may offer a more gentle and effective way to manage diabetes, minimizing the risks associated with traditional treatments. It's like finding a new source of water in the desert, one that is both nourishing and refreshing.

Dr. Camel's Conclusion

The search for better diabetes treatments is a journey of discovery, like a caravan crossing the desert. This review provides valuable insights into the potential of glibenclamide derivatives to improve patient care, offering a glimmer of hope for a brighter future in diabetes management.

Date :
  1. Date Completed 2018-04-27
  2. Date Revised 2018-11-01
Further Info :

Pubmed ID

27316908

DOI: Digital Object Identifier

CDT-EPUB-76567

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SNS
PICO Info
in preparation
Languages

English

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