Post-crizotinib management of effective ceritinib therapy in a patient with ALK-positive non-small cell lung cancer.

Author: MambetsarievIsa, SalgiaRavi, WonBrian

Paper Details 
Original Abstract of the Article :
BACKGROUND: We report the re-biopsied diagnosis of a patient with anaplastic lymphoma receptor tyrosine kinase (ALK)-positive lung adenocarcinoma successfully treated with ceritinib 450 mg/day taken with food following disease progression and gastrointestinal intolerance to crizotinib. CASE PRESENT...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969677/

データ提供:米国国立医学図書館(NLM)

A Successful Switch: Ceritinib After Crizotinib for ALK-Positive Lung Cancer

The field of [oncology] is constantly seeking new and effective treatments for [lung cancer]. This research presents a case report of a patient with [anaplastic lymphoma receptor tyrosine kinase (ALK)-positive lung adenocarcinoma] who successfully transitioned from [crizotinib] to [ceritinib] therapy after experiencing disease progression and gastrointestinal intolerance to crizotinib.

A Promising Second-Line Treatment

The research demonstrates that [ceritinib] can be an effective and well-tolerated second-line treatment option for patients with [ALK-positive lung adenocarcinoma] who have progressed on [crizotinib] therapy. The patient in this case report experienced a favorable response to [ceritinib] at a dosage of [450 mg/day] when taken with food, without experiencing any further gastrointestinal side effects. This encouraging result highlights the potential of [ceritinib] as a valuable alternative for patients who are unable to tolerate [crizotinib].

Hope for a Brighter Future in Lung Cancer Treatment

This case report provides a ray of hope in the desert of [lung cancer] treatment. The successful transition from [crizotinib] to [ceritinib] therapy showcases the potential of personalized approaches to treatment, taking into account individual patient responses and tolerability. This research underscores the ongoing efforts to develop novel therapies and improve outcomes for patients with [ALK-positive lung adenocarcinoma].

Dr. Camel's Conclusion

This research, like a caravan finding a refreshing oasis in the arid landscape of lung cancer, provides a beacon of hope for patients seeking alternative treatment options. The successful transition from crizotinib to ceritinib highlights the importance of personalized medicine and the ongoing quest for effective therapies that improve patient outcomes. This case report offers a glimmer of optimism in the fight against lung cancer.

Date :
  1. Date Completed 2017-09-26
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27480287

DOI: Digital Object Identifier

PMC4969677

SNS
PICO Info
in preparation
Languages

English

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