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The effects of methylphenidate and propranolol on the interplay between induced-anxiety and working memory.

Author: DavisAndrew, ErnstMonique, GrillonChristian, LagoTiffany

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Anxiety affects working memory (WM), and how this interaction works depends on factors like how difficult a task is. This research aims to understand how anxiety influences WM and how that can guide treatment approaches. The study will investigate the effects of two medications: propranolol, which blocks the physical effects of anxiety, and methylphenidate, which improves focus. The study aims to determine if these medications improve WM by reducing anxiety or by enhancing cognitive processes.
Paper Details　
Original Abstract of the Article :
Research documents a reciprocal impact of anxiety on working memory (WM), although its strength and direction depend on factors like task difficulty. A better understanding of these factors may generate insights into cognitive mechanisms of action involved in anxiety, culminating into treatment impl...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27492789

データ提供：米国国立医学図書館（NLM）

The Interplay Between Anxiety and Working Memory

This study explores the complex relationship between anxiety and working memory, the cognitive system responsible for holding and manipulating information over short periods. The authors investigated the effects of methylphenidate, a stimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD), and propranolol, a beta-blocker medication used to manage anxiety, on the interplay between induced anxiety and working memory performance.

Anxiety's Impact on Working Memory

The study found that propranolol, by blocking the physiological effects of anxiety, may also reduce anxiety's interference with working memory. Conversely, methylphenidate, by improving task-directed attention, may either reduce anxiety or enhance cognitive efficiency to free up processing resources for dealing with anxiety. These findings suggest that medications targeting different aspects of anxiety and cognitive function can influence the complex relationship between anxiety and working memory performance.

Health Implications and Lifestyle Considerations

This study highlights the complex relationship between anxiety and cognitive function. It underscores the importance of considering the potential cognitive impacts of medications used to manage anxiety. It also suggests that interventions aimed at improving cognitive function, such as those used for ADHD, could potentially influence the impact of anxiety on working memory. Consulting with a healthcare professional to discuss individual needs and appropriate treatment options is crucial for managing anxiety and its potential cognitive effects.

Dr.Camel's Conclusion

This study offers a valuable glimpse into the intricate interplay between anxiety and cognitive function. It underscores the importance of considering the broader impact of medications on both mental and cognitive well-being. Further research is needed to better understand the complex relationship between anxiety, working memory, and medication effects, paving the way for more targeted and effective treatment approaches.
Date :
  1. Date Completed 2017-11-24
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

27492789

DOI: Digital Object Identifier

NIHMS808743

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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