[Ergotism due to simultaneous use of ergot alkaloids and high activity antiretroviral therapy].

Author: Blanco LSergio, Cifuentes MDaniel, Ramírez FCamila

Paper Details 
Original Abstract of the Article :
High activity antiretroviral therapy may exacerbate the activity of ergot alkaloids due to an inhibition of cytochrome P450. We report a 57 years old female with AIDS treated with lamivudine, zidovudine, atazanavir, ritonavir and cotrimoxazole presenting with ischemic signs in the four limbs. There ...See full text at original site
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引用元:
https://doi.org/10.4067/S0034-98872016000600017

データ提供:米国国立医学図書館(NLM)

Ergotism: A Rare but Serious Side Effect

Ergotism is a rare but serious condition caused by the ingestion of ergot alkaloids, substances produced by certain fungi. This study describes a case of ergotism in a patient with AIDS, highlighting the potential for drug interactions to exacerbate the effects of ergot alkaloids. The case underscores the importance of careful medication management and awareness of potential drug interactions.

The Importance of Drug Interaction Monitoring

The study demonstrates that high-activity antiretroviral therapy, commonly used to treat HIV/AIDS, can increase the risk of ergotism by inhibiting the metabolism of ergot alkaloids. This interaction highlights the crucial role of careful medication management and awareness of potential drug interactions. Healthcare professionals must be vigilant about identifying potential interactions, especially in patients taking multiple medications, to minimize the risk of adverse effects.

Navigating the Complexities of Medication Management

This case underscores the importance of open communication between patients and their healthcare providers. It's essential for patients to inform their doctors about all the medications they are taking, including over-the-counter drugs and supplements. This allows healthcare providers to identify potential drug interactions and take appropriate steps to prevent or manage them. By working together, patients and their doctors can navigate the complexities of medication management and achieve the best possible outcomes.

Dr. Camel's Conclusion

Imagine a camel caravan crossing a vast desert, each camel carrying a unique load of supplies. Just as different types of cargo can interact and cause problems, different medications can also interact and create unforeseen consequences. This study reminds us that even rare events, like ergotism, can emerge from the complex interplay of medications. Open communication and careful medication management are essential for a safe and successful journey through the desert of healthcare.

Date :
  1. Date Completed 2017-06-30
  2. Date Revised 2017-06-30
Further Info :

Pubmed ID

27598502

DOI: Digital Object Identifier

10.4067/S0034-98872016000600017

Related Literature

SNS
PICO Info
in preparation
Languages

Spanish

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