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Primary Care Screening and Treatment for Latent Tuberculosis Infection in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force.

Author: AmickHalle R, BolandErin, FeltnerCynthia, HalpernMichael, JonasDaniel E, KahwatiLeila C, WeberRachel Palmieri, WoodellCarol L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are moderately sensitive and highly specific for latent tuberculosis infection (LTBI) in countries with low TB burden. While treatment with isoniazid reduced the risk of active TB, it was associated with a higher risk of hepatotoxicity compared to placebo or rifampin. Further research is needed to evaluate the benefits and harms of LTBI screening.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: Five to ten percent of individuals with latent tuberculosis infection (LTBI) progress to active tuberculosis (TB) disease. Identifying and treating LTBI is a key component of the strategy for reducing the burden of TB disease. OBJECTIVE: To review the evidence about targeted screening a...See full text at original site
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引用元：
https://doi.org/10.1001/jama.2016.10357

データ提供：米国国立医学図書館（NLM）

Latent Tuberculosis Infection: A Hidden Desert Threat

The field of [public health] faces a persistent challenge in managing [latent tuberculosis infection (LTBI)], a condition that affects a significant portion of the global population. This study, utilizing a [systematic review] approach, evaluates the evidence for [primary care screening and treatment] of LTBI in [adults]. The authors aim to provide guidance for the [US Preventive Services Task Force] in updating its recommendations for LTBI screening and treatment.

Identifying and Treating LTBI: A Vital Oasis in the Desert

The study's findings emphasize the importance of [early identification and treatment] of LTBI to prevent progression to [active tuberculosis (TB) disease]. The authors highlight the effectiveness of [tuberculin skin tests (TSTs)] and [interferon-gamma release assays (IGRAs)] in detecting LTBI, and they underscore the role of [isoniazid] and [rifapentine plus isoniazid] in reducing the risk of active TB. This research is akin to mapping the vast and potentially dangerous desert of LTBI, identifying the key resources (screening and treatment) necessary for preventing the spread of this disease.

Protecting the Community: A Collective Effort

The study's findings emphasize the need for [ongoing surveillance and preventive measures] to address the threat of TB. The authors highlight the importance of [public health initiatives] that promote awareness, facilitate early detection, and ensure access to effective treatment for LTBI. This collective effort, akin to a coordinated caravan traversing a desert, is essential for preventing the spread of TB and protecting vulnerable populations.

Dr. Camel's Conclusion

This study underscores the crucial need for effective screening and treatment strategies to address the hidden threat of LTBI. The research provides valuable insights into the best practices for preventing the progression to active TB and ensuring the health and well-being of individuals and communities.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27599332

DOI: Digital Object Identifier

10.1001/jama.2016.10357

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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