Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis.

Author: CarralotJean-Philippe, LiuXiu Fen, NiederfellnerGerhard, PastanIra, PrunottoMarco, XiangLaiman, ZhouQi

Paper Details 
Original Abstract of the Article :
RG7787 is a mesothelin-targeted immunotoxin designed to have low-immunogenicity, high-cytotoxic activity and fewer side effects. RG7787 kills many types of mesothelin-expressing cancer cells lines and causes tumor regressions in mice. Safety and immunogenicity of RG7787 is now being assessed in a ph...See full text at original site
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引用元:
https://doi.org/10.1073/pnas.1611481113

データ提供:米国国立医学図書館(NLM)

RG7787: A Powerful Weapon Against Mesothelin-Expressing Cancers

The fight against cancer is a challenging journey, and developing effective treatments for mesothelin-expressing cancers is a crucial objective. This research investigates the potential of RG7787, a mesothelin-targeted immunotoxin, as a powerful weapon against these aggressive cancers. The study explores the synergistic effects of RG7787 and actinomycin D, a potent transcription inhibitor, demonstrating a significant increase in cancer cell killing. This finding suggests that combining these two agents may offer a promising approach for treating mesothelin-expressing cancers.

RG7787: A Powerful Weapon Against Mesothelin-Expressing Cancers

This study provides evidence that the combination of RG7787 and actinomycin D is a potent strategy for treating mesothelin-expressing cancers. The researchers observed a significant synergistic effect, resulting in enhanced cancer cell killing and tumor regression. This finding is encouraging, as it offers a potential new approach for tackling these challenging cancers.

Navigating the Desert of Cancer Treatment

This study underscores the importance of exploring innovative strategies for combating cancer. The researchers' findings demonstrate that combining targeted therapies, like RG7787, with existing treatments, like actinomycin D, can significantly enhance therapeutic efficacy. Just as camels navigate the vast and unpredictable desert, researchers must continue to explore diverse approaches to cancer treatment, seeking novel combinations and strategies to improve patient outcomes.

Dr.Camel's Conclusion

This study highlights the potential of combining RG7787 and actinomycin D as a powerful strategy for treating mesothelin-expressing cancers. The findings suggest that this combination may offer a significant therapeutic advantage, enhancing cancer cell killing and promoting tumor regression. This research underscores the importance of exploring innovative therapeutic approaches for combating cancer, seeking novel combinations and strategies to improve patient outcomes.

Date :
  1. Date Completed 2018-01-25
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

27601652

DOI: Digital Object Identifier

10.1073/pnas.1611481113

Related Literature

SNS
PICO Info
in preparation
Languages

English

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