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Effects of autologous platelet transfusion on platelet inhibition in ticagrelor-treated and clopidogrel-treated subjects.
Author: AnderssonT L G, CarlsonG F, NylanderS, TengR
Original Abstract of the Article :
Essentials Limited data on hemostatic benefits of platelet transfusion (PT) exist. 44 healthy subjects had a single dose of ticagrelor or clopidogrel ± autologous PT post-dosing. PT did not reverse ticagrelor's antiplatelet effects and had minimal impact post clopidogrel. Post-ticagrelor, PT is unli...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/27653814
データ提供:米国国立医学図書館(NLM)
Platelet Transfusion in Ticagrelor and Clopidogrel-Treated Subjects
In the field of hematology, understanding the effects of platelet transfusion (PT) on platelet inhibition is crucial for managing patients undergoing antiplatelet therapy. This study investigates the effects of autologous PT on platelet inhibition in healthy subjects treated with ticagrelor or clopidogrel. The authors conducted a controlled study to determine if PT could reverse the antiplatelet effects of these medications. The study aimed to provide valuable insights into the potential benefits and limitations of PT in patients receiving antiplatelet therapy. The study concludes that PT did not significantly reverse the antiplatelet effects of ticagrelor and had only a minimal impact on clopidogrel-induced platelet inhibition.
Platelet Transfusion: Limited Impact
The study found that PT did not effectively reverse the antiplatelet effects of ticagrelor. This suggests that PT may not be a viable option for reversing the antiplatelet effects of this medication. Imagine a camel caravan crossing a desert with a loose rope. PT, like a loose rope, does not provide sufficient support to counteract the strong antiplatelet effects of ticagrelor.
Further Research Needed
The study's findings highlight the need for further research to better understand the role of PT in patients receiving antiplatelet therapy. It underscores the importance of careful consideration and personalized management when considering PT in these patients.
Dr.Camel's Conclusion
This study reminds us that the desert of hematology is full of complex interactions. PT, like a desert oasis, can be beneficial in certain situations, but its effectiveness can be limited. The study emphasizes the need for careful consideration and personalized management when using PT in patients receiving antiplatelet therapy.
Date :
- Date Completed 2017-12-25
- Date Revised 2023-08-29
Further Info :
Related Literature
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