Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.

Author: GroeneveldGeert Jan, GuanZheng, KlaassenErica S, MerkusFrans W H M, SchrierLenneke, TukBert, ZuikerRob, van GervenJoop M A, van der GeestRonald

Paper Details 
Original Abstract of the Article :
AIM: To evaluate the pharmacokinetics, pharmacodynamics, nasal tolerance and effects on sedation of a highly concentrated aqueous intranasal midazolam formulation (Nazolam) and to compare these to intravenous midazolam. METHODS: In this four-way crossover, double-blind, double-dummy, randomized, pl...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346864/

データ提供:米国国立医学図書館(NLM)

Intranasal Midazolam: A New Route to Sedation

Conscious sedation is a valuable tool in medical procedures, but it often involves the inconvenience and potential risks of intravenous administration. This research explores the safety and efficacy of a highly concentrated intranasal midazolam formulation, offering a potential alternative route for sedation.

The study compared the pharmacokinetics, pharmacodynamics, and nasal tolerance of intranasal midazolam to intravenous midazolam. The researchers found that intranasal midazolam achieved comparable sedation levels to intravenous midazolam, demonstrating its potential as a viable alternative for conscious sedation.

Intranasal Midazolam: A Convenient and Effective Option

This research suggests that intranasal midazolam could offer a more convenient and less invasive approach to conscious sedation, potentially reducing patient anxiety and improving overall patient experience.

Navigating Sedation: Exploring New Horizons

The development of new and effective methods for sedation is crucial for improving patient comfort and safety during medical procedures. This research highlights the potential of intranasal midazolam to provide a valuable alternative to traditional intravenous methods.

Dr. Camel's Conclusion

The search for new and better ways to administer sedation is like searching for a hidden oasis in a vast desert. This research provides a promising new path, demonstrating the potential of intranasal midazolam to offer a convenient and effective alternative to traditional methods. It's a reminder that the pursuit of innovation in medicine can lead to significant improvements in patient care and well-being.

Date :
  1. Date Completed 2017-11-28
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

27780297

DOI: Digital Object Identifier

PMC5346864

SNS
PICO Info
in preparation
Languages

English

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