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Impact of Hodgkin or non-Hodgkin lymphoma and their treatments on sperm aneuploidy: a prospective study by the French CECOS network.

Author: AugerJacques, BerthautIsabelle, BoryeRemi, BrugnonFlorence, BujanLouis, DaudinMyriam, HennebicqSylviane, Le MitouardMarine, MartinezGuillaume, MoinardNathalie, RavelCélia, RivesNathalie, SaiasJacqueline, SzermanEthel, ThomasClaire, WalschaertsMarie

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study found that Hodgkin and non-Hodgkin lymphoma patients had higher rates of sperm aneuploidy before treatment than healthy men. Treatment with chemotherapy regimens like ABVD or CHOP/MOPP-ABV significantly lowered sperm production and increased aneuploidy rates, with the effects lasting up to 2 years after treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospi...See full text at original site
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引用元：
https://doi.org/10.1016/j.fertnstert.2016.10.001

データ提供：米国国立医学図書館（NLM）

Impact of Lymphoma on Sperm Aneuploidy

This study, like a well-worn camel trail through the desert, delves into the impact of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) on sperm production and aneuploidy. It's a crucial research area, as these cancers and their treatments can have a significant impact on a man's fertility. The researchers used a prospective study design, analyzing lymphoma patients before treatment and at intervals of 3, 6, 12, and 24 months after treatment. They compared these results to a control group of healthy men.

Lymphoma's Impact on Sperm Aneuploidy

The results show that even before treatment, men with HL and NHL had altered semen characteristics and higher sperm aneuploidy rates compared to the control group. This is like finding an oasis in the desert that is slightly off-kilter, which is a sign that something is amiss. The study also revealed that treatment regimens, including ABVD ± radiotherapy and CHOP/MOPP-ABV, significantly lowered sperm production in the short term (3 and 6 months). Interestingly, the aneuploidy rate increased significantly only at 3 months after ABVD ± radiotherapy, but returned to lower than pre-treatment values later. However, the CHOP/MOPP-ABV treatment group took longer, with semen characteristics and aneuploidy rate not returning to normal levels until 2 years after treatment.

The Importance of Counseling

This research is crucial for understanding the implications of lymphoma and its treatment on male fertility. It highlights the need for comprehensive counseling for patients, who may experience a transient but significant impact on their sperm aneuploidy. It's like navigating a vast desert, where knowing the terrain and potential pitfalls is crucial for a successful journey.

Dr.Camel's Conclusion

This study emphasizes the importance of understanding the impact of lymphoma and its treatments on sperm aneuploidy. It sheds light on the need for counseling and support for patients navigating the complexities of this disease. As a wise camel navigates the desert, understanding the challenges and risks is essential for a successful journey. This research is like a beacon in the vast desert of male fertility, offering valuable insight and guidance.

Date :
  1. Date Completed 2017-06-13
  2. Date Revised 2017-12-24
Further Info :

Pubmed ID

27810161

DOI: Digital Object Identifier

10.1016/j.fertnstert.2016.10.001

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English

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