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Valproate for schizophrenia.

Author: HelferBartosz, LeuchtStefan, LiChunbo, WangYijun, XiaJun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Adding valproate to antipsychotic treatment resulted in more clinically significant response than adding placebo to antipsychotic drugs (14 RCTs, n = 1049, RR 1.31, 95% CI 1.16 to 1.47, I2 = 55%). However, this evidence was entirely based on open RCTs. Moreover, valproate was associated with a number of adverse events among which sedation and dizziness appeared significantly more frequently than in the control groups.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Many people with schizophrenia do not achieve a satisfactory treatment response with ordinary antipsychotic drug treatment. In these cases, various add-on medications are used, and valproate is one of these. OBJECTIVES: To examine whether:1. valproate alone is an effective treatment for...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734130/

データ提供：米国国立医学図書館（NLM）

Valproate's Potential in Schizophrenia: A Comprehensive Review

Schizophrenia, a complex mental health condition, can be challenging to treat. This review takes us on a journey through the world of psychiatric research, exploring the potential of valproate, an anticonvulsant medication, in managing schizophrenia. The review delves into the evidence, examining whether valproate can be effective on its own or as an adjunct to antipsychotic medications, much like traversing a desert landscape, seeking a path to improved well-being.

Valproate: A Potential Adjunct Therapy for Schizophrenia

The review found limited evidence suggesting that valproate may be effective as an adjunct to antipsychotic treatment for overall clinical response, particularly for symptoms like excitement and aggression. However, the evidence was primarily based on open-label randomized controlled trials, requiring further research to confirm these findings. It's like finding a promising trail in the desert but needing more exploration to confirm its viability.

Navigating the Complexities of Schizophrenia Treatment

This review highlights the complexities of schizophrenia treatment and the need for further research to explore the potential of valproate as an adjunct therapy. It emphasizes the importance of carefully monitoring for adverse events, such as sedation and dizziness, and tailoring treatment plans to individual patient needs, much like navigating a desert with caution and adaptability.

Dr. Camel's Conclusion

This review underscores the ongoing search for effective treatments for schizophrenia. While valproate may hold promise as an adjunct therapy, further research is needed to solidify its role. It's like finding a potential oasis in the desert, but we need to carefully assess its resources before making it our destination.

Date :
  1. Date Completed 2017-01-10
  2. Date Revised 2023-09-12
Further Info :

Pubmed ID

27884042

DOI: Digital Object Identifier

PMC6734130

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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