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Systematic review with meta-analysis: recurrence of Crohn's disease after total colectomy with permanent ileostomy.

Author: DulaiP S, FarrellA M, FumeryM, MeirickP, RamamoorthyS, SandbornW J, SinghS

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This systematic review and meta-analysis evaluated the rate, risk factors, and outcomes of Crohn's disease (CD) recurrence after total colectomy with permanent ileostomy (TC-PI). The pooled clinical recurrence rate after TC-PI was 28%, with a 5-year median cumulative rate of 23.5% and a 10-year median cumulative rate of 40%. The surgical recurrence rate was 16%. History of ileal disease was associated with a 3.2 times higher risk of recurrence.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Subtotal or total colectomy or proctocolectomy with permanent ileostomy (TC-PI) may be a treatment option for medically refractory colonic Crohn's disease (CD). AIM: To perform a systematic review and meta-analysis to evaluate the rate, risk factors and outcomes of CD recurrence after T...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27928830

データ提供：米国国立医学図書館（NLM）

A New Chapter in Crohn's Disease Management: Examining Recurrence After Total Colectomy

Crohn's disease, an inflammatory bowel disorder, can be a challenging and unpredictable journey. This study delves into the world of total colectomy with permanent ileostomy (TC-PI), a surgical procedure often considered for medically refractory colonic Crohn's disease. The researchers examined the rate and risk factors for disease recurrence after this procedure, seeking to better understand its long-term implications.

The Journey After TC-PI: Unveiling the Risks of Recurrence

The study found that the risk of clinical recurrence after TC-PI was significant, with approximately 28% of patients experiencing a return of symptoms. The study identified several factors associated with a higher risk of recurrence, including a history of ileal disease and penetrating disease. These findings highlight the importance of careful patient selection and ongoing medical management after TC-PI.

Navigating the Desert of Crohn's Disease: A Need for Ongoing Vigilance

This study underscores the need for ongoing vigilance in managing Crohn's disease, even after surgical intervention. The significant risk of recurrence highlights the importance of close monitoring and proactive medical treatment to minimize the impact of this challenging condition. This research reminds us that the journey with Crohn's disease is often a long one, requiring ongoing care and support.

Dr.Camel's Conclusion

This study provides valuable insights into the long-term implications of TC-PI for patients with colonic Crohn's disease. The significant risk of recurrence highlights the importance of careful patient selection and ongoing medical management after this procedure. This research emphasizes the need for continued vigilance in managing Crohn's disease, even after surgical intervention.
Date :
  1. Date Completed 2017-09-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27928830

DOI: Digital Object Identifier

NIHMS830596

SNS
PICO Info
in preparation
Languages

English

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