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High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells.
Author: KlingmüllerUrsula, KuchenovDmitry, LaketaVibor, SalopiataFlorian, SchultzCarsten, SteinFrank
Original Abstract of the Article :
Essential characteristics of cellular signaling networks include a complex interconnected architecture and temporal dynamics of protein activity. The latter can be monitored by Förster resonance energy transfer (FRET) biosensors at a single-live-cell level with high temporal resolution. However, the...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193178/
データ提供:米国国立医学図書館(NLM)
Mapping the Desert of Cellular Signaling: A High-Content Imaging Platform
The intricate world of cellular signaling networks is a fascinating landscape, filled with complex interactions and dynamic processes. This study introduces a novel high-content imaging platform (FMIP) that allows researchers to navigate this intricate terrain with greater precision. The authors, like explorers equipped with advanced tools, utilize Förster resonance energy transfer (FRET) biosensors to monitor the activity of multiple signaling pathways simultaneously, shedding light on the complex interplay between various cellular processes. The study's findings demonstrate the capabilities of FMIP in revealing the crosstalk between different signaling networks, identifying signaling perturbations caused by mutations, and assessing the effects of therapeutic inhibitors. This research offers a powerful tool for understanding cellular signaling, paving the way for more effective drug development and personalized medicine.Unlocking the Secrets of Cellular Signaling
This study introduces a revolutionary tool for exploring the intricate world of cellular signaling. The FMIP platform offers a powerful new lens for understanding the complex interactions and dynamic processes within cells, paving the way for more targeted and effective drug development. This journey into the desert of cellular signaling is constantly evolving, and this research provides a valuable compass for navigating this complex landscape.Navigating the Desert of Cellular Complexity
As a desert wanderer, I've always been fascinated by the complexity of the natural world, from the intricate patterns of sand dunes to the complex interactions within ecosystems. This study reminds me of the incredible complexity of the cellular world, a vast desert of interconnected processes. The FMIP platform offers a powerful tool for navigating this complex terrain, providing a deeper understanding of cellular signaling and its implications for health and disease.Dr. Camel's Conclusion
This study introduces a groundbreaking high-content imaging platform (FMIP) that allows researchers to simultaneously monitor multiple signaling pathways in living cells. This innovative tool offers a powerful new lens for understanding the complex interactions and dynamic processes within cells, paving the way for more targeted and effective drug development.Date :
- Date Completed n.d.
- Date Revised 2019-11-20
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