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Liver Apparent Diffusion Coefficient Changes during Telaprevir-Based Therapy for Chronic Hepatitis C.

Author: AkanselGür, AkhanSıla, AltunokElif Sargın, AynıoğluAynur, GürbüzYeşim, GürcanNagihan İnan, SakçıZakir, SarisoyHasan Tahsin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Diffusion-weighted imaging (DWI) was used to assess liver parenchymal changes in patients with chronic hepatitis C virus (HCV) during telaprevir-based triple therapy. The study found that liver ADC values were significantly lower in fibrotic liver parenchyma compared to healthy liver parenchyma. However, a discriminative threshold value for fibrosis staging was not found. ADC values showed a decline with increasing fibrosis stages, but no statistically significant correlation was observed. Telaprevir therapy significantly decreased liver ADC values, which returned to baseline values after telaprevir cessation. This indicates that DWI can potentially assess antiviral drug effects on liver parenchyma.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Diffusion-weighted imaging (DWI) has become an established diagnostic modality for the evaluation of liver parenchymal changes in diseases such as diffuse liver fibrosis. AIMS: To evaluate the parenchymal apparent diffusion coefficient value (ADC) changes using diffusion-weighted imagin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156470/

データ提供：米国国立医学図書館（NLM）

Liver Apparent Diffusion Coefficient Changes during Telaprevir-Based Therapy

This study explores the potential of diffusion-weighted imaging (DWI) to assess changes in liver parenchyma during telaprevir-based triple therapy for chronic hepatitis C. The researchers used DWI to measure the apparent diffusion coefficient (ADC) values in the livers of patients undergoing telaprevir-based treatment, comparing these values with those of healthy individuals. The findings suggest that DWI can detect changes in liver ADC values during telaprevir therapy, potentially providing a non-invasive tool to monitor treatment response and assess liver health.

DWI and Telaprevir-Based Therapy

The study found that liver ADC values were significantly lower in patients with liver fibrosis compared to healthy individuals. While DWI did not allow for precise staging of liver fibrosis, it did detect significant changes in ADC values during telaprevir therapy, suggesting that DWI may be useful for monitoring treatment response and assessing liver health during treatment.

Hepatitis C Treatment and Liver Health

The study highlights the potential of DWI as a non-invasive tool for assessing liver health during treatment for chronic hepatitis C. Further research is needed to explore the use of DWI for monitoring treatment response and predicting long-term outcomes in patients with hepatitis C.

Dr.Camel's Conclusion

Imagine a camel caravan crossing a desert, encountering an area with a vast sand dune. DWI is like a powerful telescope that can help the caravan navigate the sand dune, providing valuable information about the terrain's composition and potential hazards. Telaprevir-based therapy is like a map that guides the caravan through the desert, ensuring its safe and effective passage. This research suggests that DWI can be a valuable tool for monitoring the caravan's journey, providing insights into the effects of the therapy and the overall health of the camels.
Date :
  1. Date Completed n.d.
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

27994911

DOI: Digital Object Identifier

PMC5156470

Related Literature

Article Analysis
・Effects of telaprevir
SNS
PICO Info
in preparation
Languages

English

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