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Pharmacological treatment for antipsychotic-related constipation.

Author: ClarkeMike J, Every-PalmerSusanna, Newton-HowesGiles

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
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ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
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Overview

Antipsychotic-related constipation is a common and serious side effect, particularly with clozapine. Clozapine can impair gastrointestinal motility, leading to constipation, which is reported in up to 60% of patients. While appropriate laxatives should be prescribed, there is a lack of guidance on the comparative effectiveness and safety of different laxatives for this specific population. Understanding the effectiveness and safety of treating antipsychotic-related constipation is crucial for both clinicians and patients.
Paper Details　
Original Abstract of the Article :
Antipsychotic-related constipation is a common and serious adverse effect, especially for people taking clozapine. Clozapine has been shown to impede gastrointestinal motility, leading to constipation, and has been reported in up to 60% of patients receiving clozapine. In rare cases, complications c...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465073/

データ提供：米国国立医学図書館（NLM）

Tackling Constipation: A Desert of Discomfort

Constipation is a common ailment that can feel like wandering through a desolate desert without a drop of water. For those taking [antipsychotic medications], this discomfort can be exacerbated. This study explores the challenges of [antipsychotic-related constipation], particularly with [clozapine], a medication that can have a profound impact on [gastrointestinal motility]. The researchers, like wise travelers in a harsh landscape, are seeking to map out effective and safe strategies for managing this debilitating side effect. The study highlights the urgent need for guidance on the comparative effectiveness and harms of different [laxative agents] in this population.

Finding the Right Path Through the Desert

Constipation affects up to 60% of those taking clozapine, which is a significant number. In some cases, the complications can be life-threatening, like encountering a treacherous sandstorm. This underscores the importance of understanding the effects of antipsychotic medications on the digestive system and developing effective treatments. The study's call for more research on the comparative effectiveness of different laxatives is crucial for ensuring that individuals taking antipsychotics can manage their symptoms and live a comfortable life.

The Importance of Hydration in the Desert

This research reminds us that even medications intended to improve mental health can have unintended consequences. It underscores the importance of being aware of potential side effects and seeking appropriate medical care. For those taking antipsychotics, it's essential to stay hydrated and maintain a healthy diet, just as desert travelers rely on water and sustenance to survive. This will help to prevent constipation and ensure a smoother journey through the desert of life.

Dr. Camel's Conclusion

Like a desert traveler seeking an oasis, those experiencing constipation are desperate for relief. This study, like a compass in the sand, provides valuable insights into the complexities of antipsychotic-related constipation. It encourages us to think critically about the impact of medications on our bodies and to seek appropriate guidance for managing side effects. Remember, even in the harshest deserts, there are ways to find comfort and well-being.

Date :
  1. Date Completed 2017-04-21
  2. Date Revised 2023-10-11
Further Info :

Pubmed ID

28116777

DOI: Digital Object Identifier

PMC6465073

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Languages

English

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