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Original Abstract of the Article :
Microglial NADPH oxidase is a major source of toxic reactive oxygen species produced during chronic neuroinflammation. Voltage-gated proton channel (H<sub>V</sub>1) functions to maintain the intense activity of NADPH oxidase, and channel inhibition alleviates the pathology of neurodegenerative disea...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.ejphar.2017.01.032
データ提供：米国国立医学図書館（NLM）
Antihistamines and Proton Currents in Microglial Cells: A Camel's Trek Through the Desert of Neuroinflammation
Neuroinflammation is a complex process that plays a role in various neurological disorders. Microglial cells, the immune cells of the brain, contribute to neuroinflammation by producing reactive oxygen species. This study investigates the effects of two antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. The authors used the whole-cell patch clamp technique to examine the influence of these antihistamines on proton channel activity.
A Camel's Discovery in the Desert of Neuroinflammation: A Potential New Therapeutic Target
The study found that both diphenhydramine and chlorpheniramine inhibited proton currents in BV2 microglial cells, suggesting that these antihistamines may have a direct effect on microglial activity. The researchers observed that the inhibitory effects of these antihistamines were not mediated by histamine receptors. These findings highlight the potential of antihistamines as therapeutic agents for neurodegenerative diseases and other conditions associated with proton channel abnormalities.
A Camel's Guide to Brain Health: Understanding the Complexity of Neuroinflammation
Neuroinflammation is a complex process that can contribute to various neurological disorders. This study suggests that antihistamines may have a role in modulating microglial activity and reducing neuroinflammation. While further research is needed to fully understand the mechanisms involved and to explore the therapeutic potential of antihistamines in neurodegenerative diseases, these findings offer a promising avenue for future research.
Dr. Camel's Conclusion
This research provides valuable insights into the potential of antihistamines to modulate microglial activity and reduce neuroinflammation. The study's findings suggest that antihistamines may have therapeutic potential for neurodegenerative diseases and other conditions associated with proton channel abnormalities. Further research is needed to fully understand the mechanisms involved and to explore the clinical implications of these findings.
Date :
- Date Completed 2017-05-15
- Date Revised 2017-05-15
Further Info :
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