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Potential benefits of phytochemicals against Alzheimer's disease.

Author: WightmanEmma L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Current Alzheimer's disease drugs are primarily derived from alkaloids, which while effective in attenuating cholinergic decline, can have unpleasant side effects. This paper explores terpene and phenolic phytochemicals, arguing they offer a safer alternative. These phytochemicals demonstrate efficacy in cholinesterase inhibition and target other systems like cerebral blood flow, free radical scavenging, anti-inflammation, amyloid-β neurotoxicity, glucoregulation, and neurotransmitter interactions.
Paper Details　
Original Abstract of the Article :
Our current therapeutic drugs for Alzheimer's disease are predominantly derived from the alkaloid class of plant phytochemicals. These drugs, such as galantamine and rivastigmine, attenuate the decline in the cholinergic system but, as the alkaloids occupy the most dangerous end of the phytochemical...See full text at original site
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引用元：
https://doi.org/10.1017/S0029665116002962

データ提供：米国国立医学図書館（NLM）

Phytochemicals: A Natural Approach to Alzheimer's Disease

Alzheimer's disease, a devastating neurodegenerative disorder, presents a significant challenge to researchers and clinicians alike. This research delves into the potential of phytochemicals, naturally occurring compounds found in plants, as a safer and more holistic approach to Alzheimer's treatment. The study explores the benefits of terpene and phenolic phytochemicals, highlighting their ability to target multiple aspects of the disease beyond cholinesterase inhibition, such as improving cerebral blood flow, scavenging free radicals, and reducing inflammation. This multi-faceted approach offers hope for a more comprehensive and effective treatment strategy for Alzheimer's.

Beyond Cholinesterase Inhibition: A Multifaceted Approach

The authors argue that the potential of phytochemicals in Alzheimer's treatment goes beyond simply inhibiting cholinesterase. They emphasize the importance of targeting multiple pathways involved in the disease, such as cerebral blood flow, free radical scavenging, and inflammation. This multi-faceted approach could lead to more effective treatments with fewer side effects.

Natural Remedies for a Complex Disease

The study highlights the potential of natural remedies like Ginkgo biloba, Ginseng, and resveratrol in combatting Alzheimer's. These compounds offer a safer alternative to traditional medications, with the potential to improve cognitive function and reduce the progression of the disease. The study encourages further research into the use of phytochemicals as a natural approach to Alzheimer's, a complex disease requiring a multifaceted approach.

Dr. Camel's Conclusion

This research encourages us to look beyond traditional medications and explore the potential of natural remedies for Alzheimer's. The study's findings suggest that phytochemicals, particularly terpenes and phenolics, offer a safer and more holistic approach to treating this debilitating disease. This study could lead to the development of new and effective natural therapies for Alzheimer's, offering hope for a healthier future for those affected.

Date :
  1. Date Completed 2018-03-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28143625

DOI: Digital Object Identifier

10.1017/S0029665116002962

SNS
PICO Info
in preparation
Languages

English

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