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Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci.

Author: JacobsenKirstine, KallipolitisBirgitte H, KlitgaardJanne K, KolmosHans Jørn, PoulsenMarianne Ø, RasmussenKristian Severin, SkovMarianne N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Thioridazine is a phenothiazine that has shown synergy with the antibiotic dicloxacillin in killing methicillin-resistant Staphylococcus aureus (MRSA). This study investigated whether this synergy could be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). The study found synergy in three out of four VISA strains, but not in any of the MRSE strains, suggesting that the synergy is specific to S. aureus species.
Paper Details　
Original Abstract of the Article :
We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin interme...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28255602

データ提供：米国国立医学図書館（NLM）

Synergy in the Desert: Thioridazine and Dicloxacillin

This research explores the potential for a synergistic effect between the phenothiazine thioridazine and the beta-lactam antibiotic dicloxacillin in treating staphylococcal infections. It's like combining two different desert plants to create a potent remedy. The authors, like desert healers, investigate this combination's effectiveness against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin intermediate susceptible S. aureus (VISA), and methicillin-resistant Staphylococcus epidermidis (MRSE). The study suggests that this synergistic approach could be a valuable tool in combating these drug-resistant bacteria, like finding a new weapon in the fight against a desert plague.

Harnessing the Power of Synergy: Combating Drug-Resistant Staph

This research suggests that combining thioridazine and dicloxacillin could be a potent weapon against drug-resistant staphylococcal infections. The study highlights the potential for a synergistic effect, where the combined effect of the two drugs is greater than the sum of their individual effects. It's like combining two desert resources – water and sunlight – to create a flourishing oasis.

Antibiotic Resistance: A Desert Challenge

The emergence of drug-resistant bacteria presents a significant challenge for healthcare professionals worldwide. This research suggests that exploring synergistic drug combinations could be a valuable strategy for combating these resistant strains. It's like finding new ways to combat the harsh conditions of a desert landscape, where resilience and innovation are key.

Dr.Camel's Conclusion

This research provides a compelling case for exploring the potential of synergistic drug combinations as a strategy for combatting antibiotic resistance. The study highlights the importance of seeking innovative solutions to address this growing challenge, which threatens the health and well-being of populations worldwide.
Date :
  1. Date Completed 2017-07-27
  2. Date Revised 2017-07-27
Further Info :

Pubmed ID

28255602

DOI: Digital Object Identifier

496M873

Related Literature

Article Analysis
・Effects of dicloxacillin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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