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Tadalafil in idiopathic or heritable pulmonary arterial hypertension (PAH) compared to PAH associated with connective tissue disease.

Author: DardiFabio, DentonChristopher P, EslerAnne, GalièNazzareno, HarmonCathi, LiBaohui, ManesAlessandra, MazzantiGaia, PalazziniMassimiliano, VaraneseLucio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This post hoc analysis evaluated clinical outcomes of tadalafil in patients with pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD-PAH) compared with patients with idiopathic/heritable PAH (I/H-PAH).
Paper Details　
Original Abstract of the Article :
The primary objective of this post hoc analysis was to evaluate clinical outcomes of tadalafil in patients with pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD-PAH) compared with patients with idiopathic/heritable PAH (I/H-PAH) for primary and key secondary effic...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijcard.2017.02.094

データ提供：米国国立医学図書館（NLM）

Tadalafil and Pulmonary Arterial Hypertension: A Comparative Study

Pulmonary arterial hypertension (PAH) is a serious condition affecting the heart and lungs. This study investigates the effectiveness of tadalafil, a medication used to treat PAH, in patients with two distinct forms of the disease: PAH associated with connective tissue disease (CTD-PAH) and idiopathic/heritable PAH (I/H-PAH). The study utilizes data from two clinical trials, PHIRST and PHIRST-2, to analyze clinical outcomes and safety in both groups. This approach allows for a deeper understanding of how tadalafil affects patients with different underlying causes of PAH.

Tailoring Treatment: Tadalafil's Effects on PAH Subtypes

The research found that tadalafil showed promising results in both CTD-PAH and I/H-PAH patients, demonstrating its potential as a treatment for various subtypes of PAH. This suggests that tadalafil may offer a valuable therapeutic option for a broader range of PAH patients. However, further research is needed to determine the optimal dosage and treatment strategies for each subtype.

Navigating the Oasis: Personalized PAH Treatment

The findings of this study emphasize the importance of individualized treatment approaches for PAH. Just as different desert oases offer unique resources and support, different PAH subtypes may require tailored treatment strategies. By understanding the specific needs of each patient group, we can work towards more effective and personalized treatments for this challenging disease.

Dr.Camel's Conclusion

This study underscores the importance of tailoring treatments to individual patient needs. With its careful analysis of tadalafil's effectiveness in different PAH subtypes, this research sheds valuable light on the complex landscape of this disease. By understanding the nuances of PAH and its treatment, we can continue to refine our strategies and offer better outcomes for those affected.

Date :
  1. Date Completed 2017-11-30
  2. Date Revised 2017-11-30
Further Info :

Pubmed ID

28279499

DOI: Digital Object Identifier

10.1016/j.ijcard.2017.02.094

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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